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1.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-32375025

2.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-32531248

3.

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

Sedeyn, Koen; Schepens, Bert; Saelens, Xavier.

PLoS Pathog; 15(10): e1007984, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31622448

4.

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.

Spitaels, Jan; Van Hoecke, Lien; Roose, Kenny; Kochs, Georg; Saelens, Xavier.

J Virol; 93(15)2019 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-31092574

5.

The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines.

Saelens, Xavier.

J Infect Dis; 219(Suppl_1): S68-S74, 2019 04 08.

Artículo en Inglés | MEDLINE | ID: mdl-30715367

6.

Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein.

Acar, Delphine D; Stroobants, Veerle J E; Favoreel, Herman; Saelens, Xavier; Nauwynck, Hans J.

J Gen Virol; 100(10): 1417-1430, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31483243

7.

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

Joe, Patrick Tjok; Christopoulou, Ioanna; van Hoecke, Lien; Schepens, Bert; Ysenbaert, Tine; Heirman, Carlo; Thielemans, Kris; Saelens, Xavier; Aerts, Joeri L.

J Transl Med; 17(1): 242, 2019 07 25.

Artículo en Inglés | MEDLINE | ID: mdl-31345237

8.

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells.

Van Hoecke, Lien; Raes, Laurens; Stremersch, Stephan; Brans, Toon; Fraire, Juan C; Roelandt, Ria; Declercq, Wim; Vandenabeele, Peter; Raemdonck, Koen; Braeckmans, Kevin; Saelens, Xavier.

Int J Mol Sci; 20(17)2019 Aug 30.

Artículo en Inglés | MEDLINE | ID: mdl-31480289

9.

A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study.

Langley, Joanne M; MacDonald, Lisa D; Weir, Genevieve M; MacKinnon-Cameron, Donna; Ye, Lingyun; McNeil, Shelly; Schepens, Bert; Saelens, Xavier; Stanford, Marianne M; Halperin, Scott A.

J Infect Dis; 218(3): 378-387, 2018 07 02.

Artículo en Inglés | MEDLINE | ID: mdl-29617814

10.

Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.

Verhelst, Judith; Van Hoecke, Lien; Spitaels, Jan; De Vlieger, Dorien; Kolpe, Annasaheb; Saelens, Xavier.

J Biol Chem; 292(6): 2226-2236, 2017 02 10.

Artículo en Inglés | MEDLINE | ID: mdl-28011636

11.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke, Silvie; Ehrhardt, Katrin; Kolpe, Annasaheb; El Bakkouri, Karim; Deng, Lei; Grootaert, Hendrik; Schoonooghe, Steve; Smet, Anouk; Bentahir, Mostafa; Roose, Kenny; Schotsaert, Michael; Schepens, Bert; Callewaert, Nico; Nimmerjahn, Falk; Staeheli, Peter; Hengel, Hartmut; Saelens, Xavier.

J Virol; 91(7)2017 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-28077656

12.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Maelfait, Jonathan; Roose, Kenny; Vereecke, Lars; Mc Guire, Conor; Sze, Mozes; Schuijs, Martijn J; Willart, Monique; Ibañez, Lorena Itati; Hammad, Hamida; Lambrecht, Bart N; Beyaert, Rudi; Saelens, Xavier; van Loo, Geert.

PLoS Pathog; 12(1): e1005410, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26815999

13.

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.

Van Herck, Simon; Van Hoecke, Lien; Louage, Benoit; Lybaert, Lien; De Coen, Ruben; Kasmi, Sabah; Esser-Kahn, Aaron P; David, Sunil A; Nuhn, Lutz; Schepens, Bert; Saelens, Xavier; De Geest, Bruno G.

Bioconjug Chem; 29(3): 748-760, 2018 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-29172458

14.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Söderholm, Sandra; Kainov, Denis E; Öhman, Tiina; Denisova, Oxana V; Schepens, Bert; Kulesskiy, Evgeny; Imanishi, Susumu Y; Corthals, Garry; Hintsanen, Petteri; Aittokallio, Tero; Saelens, Xavier; Matikainen, Sampsa; Nyman, Tuula A.

Mol Cell Proteomics; 15(10): 3203-3219, 2016 10.

Artículo en Inglés | MEDLINE | ID: mdl-27486199

15.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Slowicka, Karolina; Vereecke, Lars; Mc Guire, Conor; Sze, Mozes; Maelfait, Jonathan; Kolpe, Annasaheb; Saelens, Xavier; Beyaert, Rudi; van Loo, Geert.

Eur J Immunol; 46(4): 971-80, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-26677802

16.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

Cho, Ki Joon; Schepens, Bert; Moonens, Kristof; Deng, Lei; Fiers, Walter; Remaut, Han; Saelens, Xavier.

J Virol; 90(1): 611-5, 2016 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-26468526

17.

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice.

Altenburg, Arwen F; van de Sandt, Carolien E; van Trierum, Stella E; De Gruyter, Heidi L M; van Run, Peter R W A; Fouchier, Ron A M; Roose, Kenny; Saelens, Xavier; Volz, Asisa; Sutter, Gerd; de Vries, Rory D; Rimmelzwaan, Guus F.

J Virol; 90(22): 10209-10219, 2016 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-27581985

18.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

De Beuckelaer, Ans; Pollard, Charlotte; Van Lint, Sandra; Roose, Kenny; Van Hoecke, Lien; Naessens, Thomas; Udhayakumar, Vimal Kumar; Smet, Muriel; Sanders, Niek; Lienenklaus, Stefan; Saelens, Xavier; Weiss, Siegfried; Vanham, Guido; Grooten, Johan; De Koker, Stefaan.

Mol Ther; 24(11): 2012-2020, 2016 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-27506450

19.

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.

Naessens, Thomas; Schepens, Bert; Smet, Muriel; Pollard, Charlotte; Van Hoecke, Lien; De Beuckelaer, Ans; Willart, Monique; Lambrecht, Bart; De Koker, Stefaan; Saelens, Xavier; Grooten, Johan.

J Allergy Clin Immunol; 137(3): 700-9.e9, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26560044

20.

Sequence-dependent internalization of aggregating peptides.

Couceiro, José R; Gallardo, Rodrigo; De Smet, Frederik; De Baets, Greet; Baatsen, Pieter; Annaert, Wim; Roose, Kenny; Saelens, Xavier; Schymkowitz, Joost; Rousseau, Frederic.

J Biol Chem; 290(1): 242-58, 2015 Jan 02.

Artículo en Inglés | MEDLINE | ID: mdl-25391649

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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.

The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines.

Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein.

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

Delivery of Mixed-Lineage Kinase Domain-Like Protein by Vapor Nanobubble Photoporation Induces Necroptotic-Like Cell Death in Tumor Cells.

A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study.

Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice.

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses.

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.

Sequence-dependent internalization of aggregating peptides.