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1.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(5): 1004-1015.e15, 2020 05 28.

Artículo en Inglés | MEDLINE | ID: mdl-32375025

2.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Wrapp, Daniel; De Vlieger, Dorien; Corbett, Kizzmekia S; Torres, Gretel M; Wang, Nianshuang; Van Breedam, Wander; Roose, Kenny; van Schie, Loes; Hoffmann, Markus; Pöhlmann, Stefan; Graham, Barney S; Callewaert, Nico; Schepens, Bert; Saelens, Xavier; McLellan, Jason S.

Cell; 181(6): 1436-1441, 2020 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-32531248

3.

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

Sedeyn, Koen; Schepens, Bert; Saelens, Xavier.

PLoS Pathog; 15(10): e1007984, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31622448

4.

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

Joe, Patrick Tjok; Christopoulou, Ioanna; van Hoecke, Lien; Schepens, Bert; Ysenbaert, Tine; Heirman, Carlo; Thielemans, Kris; Saelens, Xavier; Aerts, Joeri L.

J Transl Med; 17(1): 242, 2019 07 25.

Artículo en Inglés | MEDLINE | ID: mdl-31345237

5.

A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study.

Langley, Joanne M; MacDonald, Lisa D; Weir, Genevieve M; MacKinnon-Cameron, Donna; Ye, Lingyun; McNeil, Shelly; Schepens, Bert; Saelens, Xavier; Stanford, Marianne M; Halperin, Scott A.

J Infect Dis; 218(3): 378-387, 2018 07 02.

Artículo en Inglés | MEDLINE | ID: mdl-29617814

6.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Van den Hoecke, Silvie; Ehrhardt, Katrin; Kolpe, Annasaheb; El Bakkouri, Karim; Deng, Lei; Grootaert, Hendrik; Schoonooghe, Steve; Smet, Anouk; Bentahir, Mostafa; Roose, Kenny; Schotsaert, Michael; Schepens, Bert; Callewaert, Nico; Nimmerjahn, Falk; Staeheli, Peter; Hengel, Hartmut; Saelens, Xavier.

J Virol; 91(7)2017 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-28077656

7.

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.

Van Herck, Simon; Van Hoecke, Lien; Louage, Benoit; Lybaert, Lien; De Coen, Ruben; Kasmi, Sabah; Esser-Kahn, Aaron P; David, Sunil A; Nuhn, Lutz; Schepens, Bert; Saelens, Xavier; De Geest, Bruno G.

Bioconjug Chem; 29(3): 748-760, 2018 03 21.

Artículo en Inglés | MEDLINE | ID: mdl-29172458

8.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Söderholm, Sandra; Kainov, Denis E; Öhman, Tiina; Denisova, Oxana V; Schepens, Bert; Kulesskiy, Evgeny; Imanishi, Susumu Y; Corthals, Garry; Hintsanen, Petteri; Aittokallio, Tero; Saelens, Xavier; Matikainen, Sampsa; Nyman, Tuula A.

Mol Cell Proteomics; 15(10): 3203-3219, 2016 10.

Artículo en Inglés | MEDLINE | ID: mdl-27486199

9.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

Cho, Ki Joon; Schepens, Bert; Moonens, Kristof; Deng, Lei; Fiers, Walter; Remaut, Han; Saelens, Xavier.

J Virol; 90(1): 611-5, 2016 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-26468526

10.

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.

Naessens, Thomas; Schepens, Bert; Smet, Muriel; Pollard, Charlotte; Van Hoecke, Lien; De Beuckelaer, Ans; Willart, Monique; Lambrecht, Bart; De Koker, Stefaan; Saelens, Xavier; Grooten, Johan.

J Allergy Clin Immunol; 137(3): 700-9.e9, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26560044

11.

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.

Cho, Ki Joon; Schepens, Bert; Seok, Jong Hyeon; Kim, Sella; Roose, Kenny; Lee, Ji-Hye; Gallardo, Rodrigo; Van Hamme, Evelien; Schymkowitz, Joost; Rousseau, Frederic; Fiers, Walter; Saelens, Xavier; Kim, Kyung Hyun.

J Virol; 89(7): 3700-11, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25609808

12.

Scop3D: three-dimensional visualization of sequence conservation.

Vermeire, Tessa; Vermaere, Stijn; Schepens, Bert; Saelens, Xavier; Van Gucht, Steven; Martens, Lennart; Vandermarliere, Elien.

Proteomics; 15(8): 1448-52, 2015 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-25641949

13.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Anastasina, Maria; Schepens, Bert; Söderholm, Sandra; Nyman, Tuula A; Matikainen, Sampsa; Saksela, Kalle; Saelens, Xavier; Kainov, Denis E.

J Gen Virol; 96(8): 2086-2091, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-25934792

14.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Cardoso, Francisco Miguel; Ibañez, Lorena Itatí; Van den Hoecke, Silvie; De Baets, Sarah; Smet, Anouk; Roose, Kenny; Schepens, Bert; Descamps, Francis J; Fiers, Walter; Muyldermans, Serge; Depicker, Ann; Saelens, Xavier.

J Virol; 88(15): 8278-96, 2014 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-24829341

15.

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

De Baets, Sarah; Schepens, Bert; Sedeyn, Koen; Schotsaert, Michael; Roose, Kenny; Bogaert, Pieter; Fiers, Walter; Saelens, Xavier.

J Virol; 87(6): 3314-23, 2013 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-23302879

16.

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.

Verhelst, Judith; Parthoens, Eef; Schepens, Bert; Fiers, Walter; Saelens, Xavier.

J Virol; 86(24): 13445-55, 2012 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-23015724

17.

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection.

Ibañez, Lorena Itatí; De Filette, Marina; Hultberg, Anna; Verrips, Theo; Temperton, Nigel; Weiss, Robin A; Vandevelde, Wesley; Schepens, Bert; Vanlandschoot, Peter; Saelens, Xavier.

J Infect Dis; 203(8): 1063-72, 2011 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-21450996

18.

Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.

Schepens, Bert; Ibañez, Lorena Itatí; De Baets, Sarah; Hultberg, Anna; Bogaert, Pieter; De Bleser, Pieter; Vervalle, Frederik; Verrips, Theo; Melero, José; Vandevelde, Wesly; Vanlandschoot, Peter; Saelens, Xavier.

J Infect Dis; 204(11): 1692-701, 2011 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-21998474

19.

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.

De Filette, Marina; Ysenbaert, Tine; Roose, Kenny; Schotsaert, Michael; Roels, Stefan; Goossens, Els; Schepens, Bert; Fiers, Walter; Saelens, Xavier.

J Gen Virol; 92(Pt 2): 301-6, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-20965983

20.

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein.

Torrey, Heather L; Kaliaperumal, Valarmathy; Bramhecha, Yogesh; Weir, Genevieve M; Falsey, Ann R; Walsh, Edward E; Langley, Joanne M; Schepens, Bert; Saelens, Xavier; Stanford, Marianne M.

Hum Vaccin Immunother; 16(9): 2007-2017, 2020 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-32530723

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Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study.

Hierarchical and Redundant Roles of Activating FcÎ³Rs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

GM-CSF treatment prevents respiratory syncytial virus-induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation.

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody.

Scop3D: three-dimensional visualization of sequence conservation.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection.

Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion.

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein.