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1.

Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.

Yang, Dong; Chu, Hin; Hou, Yuxin; Chai, Yue; Shuai, Huiping; Lee, Andrew Chak-Yiu; Zhang, Xi; Wang, Yixin; Hu, Bingjie; Huang, Xiner; Yuen, Terrence Tsz-Tai; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Zhang, Anna Jinxia; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Infect Dis; 222(5): 734-745, 2020 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-32563187

2.

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.

Chu, Hin; Chan, Jasper Fuk-Woo; Wang, Yixin; Yuen, Terrence Tsz-Tai; Chai, Yue; Hou, Yuxin; Shuai, Huiping; Yang, Dong; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chan, Ivy Hau-Yee; Zhang, Anna Jinxia; Sit, Ko-Yung; Au, Wing-Kuk; Yuen, Kwok-Yung.

Clin Infect Dis; 71(6): 1400-1409, 2020 09 12.

Artículo en Inglés | MEDLINE | ID: mdl-32270184

3.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.

Chu, Hin; Chan, Che-Man; Zhang, Xi; Wang, Yixin; Yuan, Shuofeng; Zhou, Jie; Au-Yeung, Rex Kwok-Him; Sze, Kong-Hung; Yang, Dong; Shuai, Huiping; Hou, Yuxin; Li, Cun; Zhao, Xiaoyu; Poon, Vincent Kwok-Man; Leung, Sze Pui; Yeung, Man-Lung; Yan, Jinghua; Lu, Guangwen; Jin, Dong-Yan; Gao, George Fu; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Biol Chem; 293(30): 11709-11726, 2018 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-29887526

4.

PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

Hu, Meng; Yuan, Shuofeng; Ye, Zi-Wei; Singh, Kailash; Li, Cun; Shuai, Huiping; Fai, Ng; Chow, Billy K C; Chu, Hin; Zheng, Bo-Jian.

J Gen Virol; 98(3): 364-373, 2017 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-28113045

5.

Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.

Yuan, Shuofeng; Zhang, Naru; Singh, Kailash; Shuai, Huiping; Chu, Hin; Zhou, Jie; Chow, Billy K C; Zheng, Bo-Jian.

Antimicrob Agents Chemother; 59(7): 4082-93, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25918143

6.

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung.

Chu, Hin; Hu, Bingjie; Huang, Xiner; Chai, Yue; Zhou, Dongyan; Wang, Yixin; Shuai, Huiping; Yang, Dong; Hou, Yuxin; Zhang, Xi; Yuen, Terrence Tsz-Tai; Cai, Jian-Piao; Zhang, Anna Jinxia; Zhou, Jie; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chan, Ivy Hau-Yee; Sit, Ko-Yung; Foo, Dominic Chi-Chung; Wong, Ian Yu-Hong; Ng, Ada Tsui-Lin; Cheung, Tan To; Law, Simon Ying-Kit; Au, Wing-Kuk; Brindley, Melinda A; Chen, Zhiwei; Kok, Kin-Hang; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Nat Commun; 12(1): 134, 2021 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-33420022

7.

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.

Zhang, Xi; Chu, Hin; Wen, Lei; Shuai, Huiping; Yang, Dong; Wang, Yixin; Hou, Yuxin; Zhu, Zheng; Yuan, Shuofeng; Yin, Feifei; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Emerg Microbes Infect; 9(1): 733-746, 2020 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-32223537

8.

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-ß and IFN inducer.

Shuai, Huiping; Chu, Hin; Hou, Yuxin; Yang, Dong; Wang, Yixin; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Chai, Yue; Cai, Jian-Piao; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Infect; 81(4): e1-e10, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32707230

9.

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target.

Li, Cun; Chu, Hin; Liu, Xiaojuan; Chiu, Man Chun; Zhao, Xiaoyu; Wang, Dong; Wei, Yuxuan; Hou, Yuxin; Shuai, Huiping; Cai, Jianpiao; Chan, Jasper Fuk-Woo; Zhou, Jie; Yuen, Kwok Yung.

Emerg Microbes Infect; : 1-27, 2020 Nov 12.

Artículo en Inglés | MEDLINE | ID: mdl-33179566

10.

Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations.

Chu, Hin; Yuen, Terrence T T; Chik, Kenn K H; Yuan, Shuofeng; Shuai, Huiping; Zou, Zijiao; Wang, Yixin; Zhu, Zheng; Yang, Dong; Poon, Vincent K M; Chan, Chris C S; Zhou, Jie; Yin, Feifei; Kok, Kin-Hang; Yuen, Kwok-Yung; Chan, Jasper F W.

ACS Infect Dis; 6(7): 1745-1758, 2020 07 10.

Artículo en Inglés | MEDLINE | ID: mdl-32329611

11.

Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study.

Chu, Hin; Chan, Jasper Fuk-Woo; Yuen, Terrence Tsz-Tai; Shuai, Huiping; Yuan, Shuofeng; Wang, Yixin; Hu, Bingjie; Yip, Cyril Chik-Yan; Tsang, Jessica Oi-Ling; Huang, Xiner; Chai, Yue; Yang, Dong; Hou, Yuxin; Chik, Kenn Ka-Heng; Zhang, Xi; Fung, Agnes Yim-Fong; Tsoi, Hoi-Wah; Cai, Jian-Piao; Chan, Wan-Mui; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Zhou, Jie; Lung, David Christopher; Kok, Kin-Hang; To, Kelvin Kai-Wang; Tsang, Owen Tak-Yin; Chan, Kwok-Hung; Yuen, Kwok-Yung.

Lancet Microbe; 1(1): e14-e23, 2020 May.

Artículo en Inglés | MEDLINE | ID: mdl-32835326

12.

SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19.

Chu, Hin; Fuk-Woo Chan, Jasper; Wang, Yixin; Tsz-Tai Yuen, Terrence; Chai, Yue; Shuai, Huiping; Yang, Dong; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Hou, Yuxin; Cai, Jian-Piao; Zhang, Anna Jinxia; Zhou, Jie; Yuan, Shuofeng; Kai-Wang To, Kelvin; Fan-Ngai Hung, Ivan; Cheung, Tan To; Tsui-Lin Ng, Ada; Hau-Yee Chan, Ivy; Yu-Hong Wong, Ian; Ying-Kit Law, Simon; Chi-Chung Foo, Dominic; Leung, Wai-Keung; Yuen, Kwok-Yung.

Cell Mol Gastroenterol Hepatol; 2020 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-33010495

13.

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication.

Yan, Bingpeng; Chu, Hin; Yang, Dong; Sze, Kong-Hung; Lai, Pok-Man; Yuan, Shuofeng; Shuai, Huiping; Wang, Yixin; Kao, Richard Yi-Tsun; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Viruses; 11(1)2019 01 16.

Artículo en Inglés | MEDLINE | ID: mdl-30654597

14.

Establishment of a lethal aged mouse model of human respiratory syncytial virus infection.

Zhang, Ke; Li, Cun; Luo, Yu-Si; Wen, Lei; Yuan, Shuofeng; Wang, Dong; Ho-Yin Wong, Bosco; Zhao, Xiaoyu; Chiu, Man Chun; Ye, Zi-Wei; Sun, Zehua; Zhao, Hanjun; Zhang, Xiaomin; Hu, Meng; Yang, Dong; Shuai, Huiping; Wang, Yixin; He, Jie; Bose, Michael E; Henrickson, Kelly J; Huang, Jian-Dong; Zheng, Bojian; Chu, Hin; Zhou, Jie.

Antiviral Res; 161: 125-133, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30503888

15.

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza.

Zhao, Hanjun; To, Kelvin K W; Chu, Hin; Ding, Qiulu; Zhao, Xiaoyu; Li, Cun; Shuai, Huiping; Yuan, Shuofeng; Zhou, Jie; Kok, Kin-Hang; Jiang, Shibo; Yuen, Kwok-Yung.

Nat Commun; 9(1): 2358, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29907765

16.

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy.

Chan, Jasper Fuk-Woo; Zhu, Zheng; Chu, Hin; Yuan, Shuofeng; Chik, Kenn Ka-Heng; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yip, Cyril Chik-Yan; Zhang, Xi; Tsang, Jessica Oi-Ling; Zou, Zijiao; Tee, Kah-Meng; Shuai, Huiping; Lu, Gang; Yuen, Kwok-Yung.

Antiviral Res; 160: 38-47, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30326204

17.

Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice.

Ye, Zi-Wei; Yuan, Shuofeng; Poon, Kwok-Man; Wen, Lei; Yang, Dong; Sun, Zehua; Li, Cun; Hu, Meng; Shuai, Huiping; Zhou, Jie; Zhang, Mei-Yun; Zheng, Bo-Jian; Chu, Hin; Yuen, Kwok-Yung.

Front Immunol; 8: 317, 2017.

Artículo en Inglés | MEDLINE | ID: mdl-28377769

18.

Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts.

Zhao, Hanjun; Chu, Hin; Zhao, Xiaoyu; Shuai, Huiping; Wong, Bosco Ho-Yin; Wen, Lei; Yuan, Shuofeng; Zheng, Bo-Jian; Zhou, Jie; Yuen, Kwok-Yung.

Virology; 498: 1-8, 2016 11.

Artículo en Inglés | MEDLINE | ID: mdl-27525812

19.

SARS-CoV-2 infects human neural progenitor cells and brain organoids.

Zhang, Bao-Zhong; Chu, Hin; Han, Shuo; Shuai, Huiping; Deng, Jian; Hu, Ye-Fan; Gong, Hua-Rui; Lee, Andrew Chak-Yiu; Zou, Zijiao; Yau, Thomas; Wu, Wutian; Hung, Ivan Fan-Ngai; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung; Huang, Jian-Dong.

Cell Res; 30(10): 928-931, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32753756

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