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1.

New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Soares, Roberta Reis; da Silva, José Marcio Fernandes; Carlos, Bianca Cecheto; da Fonseca, Camila Campos; de Souza, Laila Salomé Araújo; Lopes, Fernanda Valério; de Paula Dias, Rafael Mafra; Moreira, Paulo Otávio Lourenço; Abramo, Clarice; Viana, Gustavo Henrique Ribeiro; de Pila Varotti, Fernando; da Silva, Adilson David; Scopel, Kézia Katiani Gorza.

Bioorg Med Chem Lett; 25(11): 2308-13, 2015 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-25920564

2.

Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.

Gonçalves, Alessandra Mirtes Marques Neves; de Lima, Aline Brito; da Silva Barbosa, Maria Cristina; de Camargos, Luiz Fernando; de Oliveira, Júlia Teixeira; de Souza Barbosa, Camila; Villar, José Augusto Ferreira Perez; Costa, André Carvalho; Silva, Isabella Viana Gomes da; Silva, Luciana Maria; de Pilla Varotti, Fernando; dos Santos, Fabio Vieira; Viana, Gustavo Henrique Ribeiro.

Mar Drugs; 12(8): 4361-78, 2014 Jul 31.

Artículo en Inglés | MEDLINE | ID: mdl-25089949

3.

Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.

de Oliveira, Michael Eder; Cenzi, Gisele; Nunes, Renata Rachide; Andrighetti, Carla Regina; de Sousa Valadão, Denia Mendes; Dos Reis, Cláudia; Simões, Cláudia Maria Oliveira; Nunes, Ricardo José; Júnior, Moacyr Comar; Taranto, Alex Gutterres; Sanchez, Bruno Antonio Marinho; Viana, Gustavo Henrique Ribeiro; de Pilla Varotti, Fernando.

Molecules; 18(12): 15276-87, 2013 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-24335577

4.

Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines.

Oliveira, Júlia Teixeira de; Franco, Filipe Nogueira; Tecchio, Kimberly Brito; Gonçalves, Alessandra Mirtes Marques Neves; Barbosa, Camila de Souza; Ribeiro, Rosy Iara Maciel de Azambuja; Viana, Gustavo Henrique Ribeiro; Santos, Vanessa J da Silva Vieira Dos; Santos, Fabio Vieira Dos.

Mutat Res; 861-862: 503294, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33551097

5.

Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity.

Silva, Marina Goulart Da; Cardoso, Jéssica Ferreira; Perasoli, Fernanda Barçante; Branquinho, Renata Tupinambá; Mourão, Renata Silva; Tavares, Harley Da Silva; Xocaira, Maria Luiza Costa Trench; Guimarães, Daniel Silqueira Martins; Viana, Gustavo Henrique Ribeiro; Varotti, Fernando De Pilla; Silva, Gisele Rodrigues Da.

Eur J Pharm Sci; 151: 105382, 2020 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-32470575

6.

Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.

Guimarães, Daniel Silqueira Martins; de Sousa Luz, Letícia Silveira; do Nascimento, Sara Batista; Silva, Lorena Rabelo; de Miranda Martins, Natália Rezende; de Almeida, Heloísa Gonçalves; de Souza Reis, Vitória; Maluf, Sarah El Chamy; Budu, Alexandre; Marinho, Juliane Aparecida; Abramo, Clarice; Carmona, Adriana Karaoglanovic; da Silva, Marina Goulart; da Silva, Gisele Rodrigues; Kemmer, Victor Matheus; Butera, Anna Paola; Ribeiro-Viana, Renato Márcio; Gazarini, Marcos Leoni; Júnior, Clébio Soares Nascimento; Guimarães, Luciana; Dos Santos, Fabio Vieira; de Castro, Whocely Victor; Viana, Gustavo Henrique Ribeiro; de Brito, Cristiana Ferreira Alves; de Pilla Varotti, Fernando.

Eur J Pharm Sci; 138: 105015, 2019 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-31344442

7.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44^+/high /CD24^-/low subset of triple-negative breast cancer cell line.

de Lima, Aline Brito; Barbosa, Camila de Souza; Gonçalves, Alessandra Mirtes Marques Neves; Santos, Fabio Vieira Dos; Viana, Gustavo Henrique Ribeiro; Varotti, Fernando de Pilla; Silva, Luciana Maria.

Chem Biol Drug Des; 90(1): 5-11, 2017 07.

Artículo en Inglés | MEDLINE | ID: mdl-27995747

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New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.

Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.

Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines.

Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity.

Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44^+/high /CD24^-/low subset of triple-negative breast cancer cell line.

Portal de Búsqueda de la BVS España

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New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.

Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.

Metabolic activation enhances the cytotoxicity, genotoxicity and mutagenicity of two synthetic alkaloids with selective effects against human tumour cell lines.

Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity.

Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high /CD24-/low subset of triple-negative breast cancer cell line.

New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44^+/high /CD24^-/low subset of triple-negative breast cancer cell line.