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1.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature; 586(7827): 113-119, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32707573

2.

Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKÎµ.

Wong, Lok-Yin Roy; Ye, Zi-Wei; Lui, Pak-Yin; Zheng, Xuyang; Yuan, Shuofeng; Zhu, Lin; Fung, Sin-Yee; Yuen, Kit-San; Siu, Kam-Leung; Yeung, Man-Lung; Cai, Zongwei; Woo, Patrick Chiu-Yat; Yuen, Kwok-Yung; Chan, Chi-Ping; Jin, Dong-Yan.

J Immunol; 205(6): 1564-1579, 2020 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-32747502

3.

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chu, Hin; Yang, Jin; Xing, Fanfan; Liu, Jieling; Yip, Cyril Chik-Yan; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Lo, Simon Kam-Fai; Chan, Kwok-Hung; Poon, Vincent Kwok-Man; Chan, Wan-Mui; Ip, Jonathan Daniel; Cai, Jian-Piao; Cheng, Vincent Chi-Chung; Chen, Honglin; Hui, Christopher Kim-Ming; Yuen, Kwok-Yung.

Lancet; 395(10223): 514-523, 2020 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-31986261

4.

Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou, Jie; Li, Cun; Sachs, Norman; Chiu, Man Chun; Wong, Bosco Ho-Yin; Chu, Hin; Poon, Vincent Kwok-Man; Wang, Dong; Zhao, Xiaoyu; Wen, Lei; Song, Wenjun; Yuan, Shuofeng; Wong, Kenneth Kak-Yuen; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chen, Honglin; Clevers, Hans; Yuen, Kwok-Yung.

Proc Natl Acad Sci U S A; 115(26): 6822-6827, 2018 06 26.

Artículo en Inglés | MEDLINE | ID: mdl-29891677

5.

Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation.

Yang, Dong; Chu, Hin; Hou, Yuxin; Chai, Yue; Shuai, Huiping; Lee, Andrew Chak-Yiu; Zhang, Xi; Wang, Yixin; Hu, Bingjie; Huang, Xiner; Yuen, Terrence Tsz-Tai; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Zhang, Anna Jinxia; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Infect Dis; 222(5): 734-745, 2020 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-32563187

6.

Serum antibody profile of a patient with COVID-19 reinfection.

To, Kelvin Kai-Wang; Hung, Ivan Fan-Ngai; Chan, Kwok-Hung; Yuan, Shuofeng; To, Wing-Kin; Tsang, Dominic Ngai-Chong; Cheng, Vincent Chi-Chung; Chen, Zhiwei; Kok, Kin-Hang; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Sep 23.

Artículo en Inglés | MEDLINE | ID: mdl-32966566

7.

Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza A(H1N1)pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chan, Jasper Fuk-Woo; Liu, Feifei; Li, Can; Chen, Yanxia; Chu, Hin; Lau, Siu-Ying; Wang, Pui; Chan, Chris Chung-Sing; Poon, Vincent Kwok-Man; Yuan, Shuofeng; To, Kelvin Kai-Wang; Chen, Honglin; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Nov 20.

Artículo en Inglés | MEDLINE | ID: mdl-33216851

8.

SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters.

Zhang, Anna Jinxia; Lee, Andrew Chak-Yiu; Chu, Hin; Chan, Jasper Fuk-Woo; Fan, Zhimeng; Li, Can; Liu, Feifei; Chen, Yanxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Cai, Jian-Piao; Wu, Kenneth Lap-Kei; Sridhar, Siddharth; Chan, Ying-Shing; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-32667973

9.

Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility.

Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Yuan, Shuofeng; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Chan, Wan-Mui; Fan, Zhimeng; Tsoi, Hoi-Wah; Wen, Lei; Liang, Ronghui; Cao, Jianli; Chen, Yanxia; Tang, Kaiming; Luo, Cuiting; Cai, Jian-Piao; Kok, Kin-Hang; Chu, Hin; Chan, Kwok-Hung; Sridhar, Siddharth; Chen, Zhiwei; Chen, Honglin; To, Kelvin Kai-Wang; Yuen, Kwok-Yung.

Clin Infect Dis; 71(9): 2428-2446, 2020 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-32215622

10.

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).

Chan, Jasper Fuk-Woo; Yuan, Shuofeng; Zhang, Anna Jinxia; Poon, Vincent Kwok-Man; Chan, Chris Chung-Sing; Lee, Andrew Chak-Yiu; Fan, Zhimeng; Li, Can; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Luo, Cuiting; Cheng, Vincent Chi-Chung; Cai, Jian-Piao; Chu, Hin; Chan, Kwok-Hung; To, Kelvin Kai-Wang; Sridhar, Siddharth; Yuen, Kwok-Yung.

Clin Infect Dis; 71(16): 2139-2149, 2020 11 19.

Artículo en Inglés | MEDLINE | ID: mdl-32472679

11.

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19.

Chu, Hin; Chan, Jasper Fuk-Woo; Wang, Yixin; Yuen, Terrence Tsz-Tai; Chai, Yue; Hou, Yuxin; Shuai, Huiping; Yang, Dong; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Cai, Jian-Piao; Zhou, Jie; Yuan, Shuofeng; Kok, Kin-Hang; To, Kelvin Kai-Wang; Chan, Ivy Hau-Yee; Zhang, Anna Jinxia; Sit, Ko-Yung; Au, Wing-Kuk; Yuen, Kwok-Yung.

Clin Infect Dis; 71(6): 1400-1409, 2020 09 12.

Artículo en Inglés | MEDLINE | ID: mdl-32270184

12.

COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing.

To, Kelvin Kai-Wang; Hung, Ivan Fan-Ngai; Ip, Jonathan Daniel; Chu, Allen Wing-Ho; Chan, Wan-Mui; Tam, Anthony Raymond; Fong, Carol Ho-Yan; Yuan, Shuofeng; Tsoi, Hoi-Wah; Ng, Anthony Chin-Ki; Lee, Larry Lap-Yip; Wan, Polk; Tso, Eugene; To, Wing-Kin; Tsang, Dominic; Chan, Kwok-Hung; Huang, Jian-Dong; Kok, Kin-Hang; Cheng, Vincent Chi-Chung; Yuen, Kwok-Yung.

Clin Infect Dis; 2020 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-32840608

13.

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.

Siu, Kam-Leung; Yuen, Kit-San; Castaño-Rodriguez, Carlos; Ye, Zi-Wei; Yeung, Man-Lung; Fung, Sin-Yee; Yuan, Shuofeng; Chan, Chi-Ping; Yuen, Kwok-Yung; Enjuanes, Luis; Jin, Dong-Yan.

FASEB J; 33(8): 8865-8877, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31034780

14.

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system.

Yuan, Shuofeng; Chan, Jasper F W; Chik, Kenn K H; Chan, Chris C Y; Tsang, Jessica O L; Liang, Ronghui; Cao, Jianli; Tang, Kaiming; Chen, Lin-Lei; Wen, Kun; Cai, Jian-Piao; Ye, Zi-Wei; Lu, Gang; Chu, Hin; Jin, Dong-Yan; Yuen, Kwok-Yung.

Pharmacol Res; 159: 104960, 2020 09.

Artículo en Inglés | MEDLINE | ID: mdl-32473310

15.

Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.

Chu, Hin; Chan, Che-Man; Zhang, Xi; Wang, Yixin; Yuan, Shuofeng; Zhou, Jie; Au-Yeung, Rex Kwok-Him; Sze, Kong-Hung; Yang, Dong; Shuai, Huiping; Hou, Yuxin; Li, Cun; Zhao, Xiaoyu; Poon, Vincent Kwok-Man; Leung, Sze Pui; Yeung, Man-Lung; Yan, Jinghua; Lu, Guangwen; Jin, Dong-Yan; Gao, George Fu; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

J Biol Chem; 293(30): 11709-11726, 2018 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-29887526

16.

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells.

Yan, Bingpeng; Zou, Zijiao; Chu, Hin; Chan, Gabriella; Tsang, Jessica Oi-Ling; Lai, Pok-Man; Yuan, Shuofeng; Yip, Cyril Chik-Yan; Yin, Feifei; Kao, Richard Yi-Tsun; Sze, Kong-Hung; Lau, Susanna Kar-Pui; Chan, Jasper Fuk-Woo; Yuen, Kwok-Yung.

Int J Mol Sci; 20(23)2019 Nov 26.

Artículo en Inglés | MEDLINE | ID: mdl-31779252

17.

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy.

Zhu, Zheng; Chu, Hin; Wen, Lei; Yuan, Shuofeng; Chik, Kenn Ka-Heng; Yuen, Terrence Tsz-Tai; Yip, Cyril Chik-Yan; Wang, Dong; Zhou, Jie; Yin, Feifei; Jin, Dong-Yan; Kok, Kin-Hang; Yuen, Kwok-Yung; Chan, Jasper Fuk-Woo.

Int J Mol Sci; 20(2)2019 Jan 17.

Artículo en Inglés | MEDLINE | ID: mdl-30658479

18.

PAN substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities.

Hu, Meng; Yuan, Shuofeng; Ye, Zi-Wei; Singh, Kailash; Li, Cun; Shuai, Huiping; Fai, Ng; Chow, Billy K C; Chu, Hin; Zheng, Bo-Jian.

J Gen Virol; 98(3): 364-373, 2017 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-28113045

19.

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication.

Yuan, Shuofeng; Chu, Hin; Zhang, Ke; Ye, Jiahui; Singh, Kailash; Kao, Richard Y T; Chow, Billy K C; Zhou, Jie; Zheng, Bo-Jian.

J Antimicrob Chemother; 71(9): 2489-97, 2016 09.

Artículo en Inglés | MEDLINE | ID: mdl-27272726

20.

Cross-protection of influenza A virus infection by a DNA aptamer targeting the PA endonuclease domain.

Yuan, Shuofeng; Zhang, Naru; Singh, Kailash; Shuai, Huiping; Chu, Hin; Zhou, Jie; Chow, Billy K C; Zheng, Bo-Jian.

Antimicrob Agents Chemother; 59(7): 4082-93, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25918143

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