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1.
BMC Surg ; 24(1): 282, 2024 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-39354456

RESUMEN

PURPOSE: To present the radiological and clinical outcomes of super-selective transcatheter renal artery embolization in patients with renal injury hemorrhage, and share our experience. METHODS: 43 patients with renal injury hemorrhage who underwent 46 SRAEs were enrolled in this retrospective review study. Records, images, and outcomes were reviewed. The individual embolic method and its observed effects were investigated. RESULTS: Angiography showed free extravasation in 25 angiograms, pseudoaneurysm in 15 angiograms, and arteriovenous fistulas in 1 angiogram. Most patients achieved initial clinical success (38/43, 88.4%), and 41 patients achieved final clinical success (41/43, 95.3%). 9/11 patients who adopted empirical embolization achieved initial clinical success (81.8%). In our study, the combination of PVA particles and micro-coils has emerged as the most commonly utilized material combination (24/46, 52.2%). Significant differences in hemoglobin levels were observed before and after the embolization procedure (p = 0.026, 95%CI: 1.03-15.54). Post-embolization clinical follow-up showed no evidence of recurrent hematuria, progression of hematoma, hypertension, and no reflux of the embolic agent. CONCLUSION: Though SRAE showed satisfactory results across a broad range of renal injury hemorrhage, there are still some aspects that need attention: (1) Surgical procedure should be understood, including the surgical site, access routes, and placement of implants, such as double-J stents. (2) In cases where identifying the bleeding point proves challenging, consider the possibility of an accessory renal artery. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2400085050, Registration Date: 30 May 2024, retrospectively, non-randomized.


Asunto(s)
Embolización Terapéutica , Hemorragia , Enfermedad Iatrogénica , Arteria Renal , Humanos , Embolización Terapéutica/métodos , Estudios Retrospectivos , Masculino , Femenino , Arteria Renal/lesiones , Arteria Renal/diagnóstico por imagen , Persona de Mediana Edad , Adulto , Hemorragia/etiología , Hemorragia/terapia , Anciano , Resultado del Tratamiento , Riñón/irrigación sanguínea , Riñón/lesiones , Adulto Joven , Angiografía , Adolescente
2.
J Vasc Interv Radiol ; 34(3): 436-444, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36414115

RESUMEN

PURPOSE: To evaluate differences in arteriographic findings and outcomes after embolization among patients with a suspected iatrogenic renal arterial injury (IRAI). MATERIALS AND METHODS: Patients at the authors' institution who underwent renal arteriography for suspected IRAIs after partial nephrectomy, biopsy, or percutaneous access over a 20-year period were included. Records, imaging, and outcomes were reviewed. Data analysis was performed using the Fisher exact or Kruskal-Wallis test. RESULTS: Ninety arteriograms were performed on 83 patients after partial nephrectomy (n = 32), biopsy (n = 27), or percutaneous access (n = 24), including for nephrostomy/ureterostomy and stone removal. The median number of days between the index procedure and arteriogram was highest (15 days) after partial nephrectomy and lowest (5 days) after biopsy (P = .0001). Embolization was performed during 76% of arteriograms. If prearteriographic imaging showed positive results for IRAIs, embolization was performed in 67% versus 33% if imaging showed negative results (P = .005). The transfusion rate was higher after biopsy than after partial nephrectomy or percutaneous access (P = .002). Acute kidney injury after arteriogram occurred in 7% of patients; however, all returned to baseline by 1 week. CONCLUSIONS: Despite the different mechanism of IRAIs in partial nephrectomy, biopsy, and percutaneous access, arteriographic findings and outcomes were overall similar among groups. Prearteriographic imaging can help identify IRAIs but cannot supersede the clinical judgment regarding indication for embolization. IRAIs can present acutely or after a long interim, although patients who underwent biopsy presented earlier and more frequently required a blood transfusion. IRAIs can be treated with embolization without permanent deleterious effects on renal function.


Asunto(s)
Traumatismos Abdominales , Lesión Renal Aguda , Embolización Terapéutica , Humanos , Arteria Renal/lesiones , Hemorragia/terapia , Angiografía , Embolización Terapéutica/métodos , Nefrectomía/métodos , Traumatismos Abdominales/terapia , Enfermedad Iatrogénica , Estudios Retrospectivos
3.
Ann Vasc Surg ; 79: 443.e1-443.e3, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34656715

RESUMEN

Abdominal trauma leads rarely to severe renal injury such as acquired arterioveinous fistula. Here, we present the case of a 46-year-old man with a history of suicide attempt by a gunshot in the abdomen. At that time, explorative laparotomy was unremarkable. He consulted 23 years later for chronic left lumbar pain and was diagnosed with an arterioveinous fistula of left renal vessels with a-10-cm aneurysm of the left renal artery. We performed a left nephrectomy and endovascular clamping was the best option to manage this giant aneurysm in a hostile abdomen.


Asunto(s)
Traumatismos Abdominales/etiología , Aneurisma/etiología , Fístula Arteriovenosa/etiología , Arteria Renal/lesiones , Venas Renales/lesiones , Lesiones del Sistema Vascular/etiología , Heridas por Arma de Fuego/complicaciones , Traumatismos Abdominales/diagnóstico por imagen , Traumatismos Abdominales/cirugía , Aneurisma/diagnóstico por imagen , Aneurisma/cirugía , Fístula Arteriovenosa/diagnóstico por imagen , Fístula Arteriovenosa/cirugía , Enfermedades Asintomáticas , Constricción , Procedimientos Endovasculares , Humanos , Masculino , Persona de Mediana Edad , Nefrectomía , Arteria Renal/diagnóstico por imagen , Arteria Renal/cirugía , Venas Renales/diagnóstico por imagen , Venas Renales/cirugía , Intento de Suicidio , Factores de Tiempo , Lesiones del Sistema Vascular/diagnóstico por imagen , Lesiones del Sistema Vascular/cirugía
4.
J Am Soc Nephrol ; 32(10): 2445-2453, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34599036

RESUMEN

BACKGROUND: Renal denervation (RDN) is an invasive intervention to treat drug-resistant arterial hypertension. Its therapeutic value is contentious. Here we examined the effects of RDN on inflammatory and infectious kidney disease models in mice. METHODS: Mice were unilaterally or bilaterally denervated, or sham operated, then three disease models were induced: nephrotoxic nephritis (NTN, a model for crescentic GN), pyelonephritis, and acute endotoxemic kidney injury (as a model for septic kidney injury). Analytical methods included measurement of renal glomerular filtration, proteinuria, flow cytometry of renal immune cells, immunofluorescence microscopy, and three-dimensional imaging of optically cleared kidney tissue by light-sheet fluorescence microscopy followed by algorithmic analysis. RESULTS: Unilateral RDN increased glomerular filtration in denervated kidneys, but decreased it in the contralateral kidneys. In the NTN model, more nephritogenic antibodies were deposited in glomeruli of denervated kidneys, resulting in stronger inflammation and injury in denervated compared with contralateral nondenervated kidneys. Also, intravenously injected LPS increased neutrophil influx and inflammation in the denervated kidneys, both after unilateral and bilateral RDN. When we induced pyelonephritis in bilaterally denervated mice, both kidneys contained less bacteria and neutrophils. In unilaterally denervated mice, pyelonephritis was attenuated and intrarenal neutrophil numbers were lower in the denervated kidneys. The nondenervated contralateral kidneys harbored more bacteria, even compared with sham-operated mice, and showed the strongest influx of neutrophils. CONCLUSIONS: Our data suggest that the increased perfusion and filtration in denervated kidneys can profoundly influence concomitant inflammatory diseases. Renal deposition of circulating nephritic material is higher, and hence antibody- and endotoxin-induced kidney injury was aggravated in mice. Pyelonephritis was attenuated in denervated murine kidneys, because the higher glomerular filtration facilitated better flushing of bacteria with the urine, at the expense of contralateral, nondenervated kidneys after unilateral denervation.


Asunto(s)
Lesión Renal Aguda/etiología , Lesión Renal Aguda/fisiopatología , Desnervación Autonómica/efectos adversos , Vasoespasmo Coronario/cirugía , Hipertensión/cirugía , Nefritis/patología , Animales , Bacterias/aislamiento & purificación , Endotoxemia/complicaciones , Femenino , Tasa de Filtración Glomerular , Inmunoglobulina G/metabolismo , Riñón/irrigación sanguínea , Lipopolisacáridos , Ratones , Nefritis/inmunología , Nefritis/metabolismo , Neutrófilos/patología , Proteinuria/etiología , Pielonefritis/microbiología , Pielonefritis/patología , Pielonefritis/fisiopatología , Arteria Renal/lesiones , Arteria Renal/cirugía
5.
Clin Radiol ; 76(2): 153.e17-153.e24, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32993880

RESUMEN

Injury to the renal artery following blunt trauma is detected increasingly due to widespread and early use of multidetector computed tomography (CT), but optimal treatment remains controversial as no guidelines are available. This review illustrates the spectrum of imaging findings of traumatic renal artery dissection based on our experience, with the aim of understanding the physiopathology of ischaemic damage to the kidney, and the process of choosing the best therapeutic strategy (conservative, endovascular, surgical). Five main patterns of traumatic renal artery dissection are described: avulsion of renal hilum; dissection of the segmental renal branches; preocclusive main renal artery dissection; renal artery stenosis without flow limitation; thrombogenic renal artery intimal tear. In the polytrauma patient, management depends on various factors (haemodynamic status, associated lesions, time of diagnosis) rather than on the degree of renal artery stenosis. Non-operative management (NOM) is the preferred option in case of non-flow-limiting dissection of the renal artery and angio-embolisation is an important adjunct to NOM in cases of active bleeding. Embolisation of the renal artery stump may be the best option in cases of occlusive dissection, as catheter manipulation carries a high risk of vessel rupture. The therapeutic window for kidney revascularisation in cases of flow-limiting dissection of main renal artery may be variable. Endovascular stenting >4 h after trauma should be performed only if residual flow with preserved parenchymal perfusion is detected at angiography. Antiplatelet therapy administration is recommended in cases of stenting, but conditioned by the bleeding risk of the patient.


Asunto(s)
Tomografía Computarizada Multidetector/métodos , Arteria Renal/diagnóstico por imagen , Arteria Renal/lesiones , Heridas no Penetrantes/diagnóstico por imagen , Heridas no Penetrantes/terapia , Tratamiento Conservador/métodos , Procedimientos Endovasculares/métodos , Humanos , Arteria Renal/cirugía , Resultado del Tratamiento
6.
Ann Vasc Surg ; 65: 286.e1-286.e4, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-31712189

RESUMEN

BACKGROUND: Renal artery (RA) dissection may occur during endovascular treatment of thoracoabdominal aneurysms. The aim of this paper is to report the use of kissing coronary stents in the renal bifurcation as a bailout solution for dissection after fenestraded/branched endovascular aortic repair (F/B-EVAR). METHODS/RESULTS: A 73-year-old male with an asymptomatic Crawford type 4 thoracoabdominal aneurysm and a concomitant right common iliac artery aneurysm was proposed for endovascular repair, consisting of thoracic endovascular aortic repair plus custom-made device F/B-EVAR, followed by staged bifurcated EVAR plus right-sided IBD. In the control angiogram of the first procedure, a distal occlusion of the left renal artery was observed and attributed to iatrogenic dissection. The 6F sheath was reintroduced and the two main branches of the RA were catheterized with 0.014 wires. Then, two coronary drug-eluting stents were used for a kissing stenting technique with good angiographic and clinical results. As planned, one week later the patient underwent an uneventful second stage procedure. Follow-up CTA at 1 year showed normal patency of the renal stents as well as aneurysm shrinking and no signs of endoleak. CONCLUSIONS: In the reported case, the use of coronary stents was a safe and long-lasting solution to rescue an iatrogenic renal artery dissection during F/B-EVAR.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/terapia , Implantación de Prótesis Vascular/instrumentación , Prótesis Vascular , Stents Liberadores de Fármacos , Procedimientos Endovasculares/instrumentación , Enfermedad Iatrogénica , Aneurisma Ilíaco/cirugía , Arteria Renal/lesiones , Lesiones del Sistema Vascular/terapia , Anciano , Disección Aórtica/diagnóstico por imagen , Disección Aórtica/etiología , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Implantación de Prótesis Vascular/efectos adversos , Procedimientos Endovasculares/efectos adversos , Humanos , Aneurisma Ilíaco/diagnóstico por imagen , Masculino , Diseño de Prótesis , Arteria Renal/diagnóstico por imagen , Resultado del Tratamiento , Lesiones del Sistema Vascular/diagnóstico por imagen , Lesiones del Sistema Vascular/etiología
7.
Urol Int ; 104(1-2): 148-155, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31846981

RESUMEN

BACKGROUND: Trauma is a major cause of death and disability worldwide. Renal injuries account for 8-10% of abdominal trauma. We aimed to describe the incidence, presentation, and management of traumatic kidney injury in our institution. METHODS: This is a retrospective analysis of all patients admitted with traumatic kidney injury at a level 1 trauma center between January 2014 and December 2017. RESULTS: During a period of 3 years, a total of 152 patients with blunt renal trauma were admitted to a level 1 trauma center; 91% of these were males, with a mean age of 32.8 ± 13.7 years. Motor vehicle crashes accounted for 68% of cases, followed by fall from height (23%). Seventy-one percent of patients had associated chest injuries, 38% had pelvis injuries, and 32% had head injury. Associated abdominal injuries included the liver (35%) and spleen (26%). The mean abdominal abbreviated injury scale was 2.8 ± 1.0; and for those with severe renal injury, it was 3.9 ± 0.9. The mean injury severity score was 24.9 ± 13.7 (31.8 ± 14.2 with renal vs. 21.9 ± 12.9 without renal injury, p = 0.004). Most of the patients were treated conservatively (93%), including severe renal injuries (grades IV and V), and 7% had surgical exploration, mainly those with severe injuries (grades IV and V). The mortality rate was 11%. CONCLUSIONS: High-grade renal injuries in hemodynamically stable patients can be managed conservatively. A multidisciplinary approach coordinated by trauma, urology, and radiology services facilitates the care of these patients in our trauma center.


Asunto(s)
Traumatismos Abdominales/diagnóstico , Riñón/lesiones , Índice de Severidad de la Enfermedad , Heridas no Penetrantes/diagnóstico , Traumatismos Abdominales/epidemiología , Accidentes de Tránsito , Adolescente , Adulto , Algoritmos , Femenino , Hemodinámica , Humanos , Incidencia , Comunicación Interdisciplinaria , Masculino , Grupo de Atención al Paciente , Qatar , Arteria Renal/lesiones , Estudios Retrospectivos , Heridas no Penetrantes/epidemiología , Adulto Joven
8.
Int Braz J Urol ; 46(2): 194-202, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32022507

RESUMEN

OBJECTIVE: To evaluate usage of renal artery embolization (RAE) for renal injuries and discuss the indications for this treatment. MATERIALS AND METHODS: A retrospective study was performed evaluating the electronic medical records of all patients with renal trauma admitted to two major comprehensive hospitals in Shantou city from January 2006 to December 2015. RESULTS: There were 264 and 304 renal traumatic patients admitted to hospital A and B, respectively. LGRT was the reason for presentation in the majority of patients (522, 91.9%). A total of 534 (94.0%) patients were treated conservatively. RAE was performed in 9 patients from 2012 to 2015 at hospital A, including in 6 patients (6/9, 66.7%) with LGRT, and 3 patients (3/9, 33.3%) with HGRT. No patient underwent interventional therapy (RAE) at hospital B during the same period. No significant differences in the operative rate of hospital A were observed between the two time periods (2006-2011 and 2012-2015). The operative rate for LGRT between the two hospitals from 2006 to 2011 and 2012 to 2015 was not significantly different. Hospital A showed a significant decrease in the rate of conservative treatment for patients with LGRT. In the univariate and multivariate analyses, the AAST renal grade both were significantly associated with undergoing RAE. CONCLUSIONS: LGRT was present in the majority of patients, and most cases of renal trauma could be treated with conservative treatment. RAE was well utilized for the treatment of renal trauma. However, some patients with LGRT were treated with unnecessary interventional therapy.


Asunto(s)
Embolización Terapéutica/métodos , Enfermedades Renales/terapia , Riñón/irrigación sanguínea , Arteria Renal/lesiones , Adolescente , Adulto , Anciano , Femenino , Humanos , Enfermedades Renales/diagnóstico por imagen , Enfermedades Renales/etiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Índices de Gravedad del Trauma , Resultado del Tratamiento , Adulto Joven
9.
Forensic Sci Med Pathol ; 16(2): 355-358, 2020 06.
Artículo en Inglés | MEDLINE | ID: mdl-31679122

RESUMEN

Blunt renal artery injury (BRAI) is a rare finding with incidence ranging from 0.05% to 0.08% among blunt abdominal trauma patients. BRAI occurs in 1% to 4% of patients with renal injury, and the most common cause is motor vehicle accidents. An unusual case of BRAI in a 47-year-old man at work is reported. The victim accidentally fell from a scaffold (approximately 3 m in height). He was transported to the hospital where he was intubated, but he died after 30 min despite the cardio-pulmonary resuscitation. Surveillance cameras showed the man falling from the scaffold, but his impact with the ground was not captured. At autopsy, except for an oval bruise on the left hypochondrium, no external injury was found. The same mark was noticed on the shirt worn by the victim. Bilateral ribs fractures were found. The abdominal cavity was filled with 2 l of fresh blood and clots as a consequence of a complete transection of the left renal artery. Investigation of the workplace revealed a partial footprint on the external side of the scaffold, matching shoes worn by the victim. On the ground, a metallic pedestrian gate with a 1 m high post was found placed just below the scaffold. It was concluded that the man hit the gate's post as intermediate impact after the fall, which caused the oval bruise, ribs fractures, and the rupture of the left renal artery without injury of the internal organs.


Asunto(s)
Accidentes por Caídas , Contusiones/patología , Arteria Renal/lesiones , Abdomen/patología , Accidentes de Trabajo , Humanos , Masculino , Persona de Mediana Edad , Arteria Renal/patología , Fracturas de las Costillas/patología
10.
World J Urol ; 36(3): 489-496, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29294163

RESUMEN

INTRODUCTION: Although many radiologists invoke the surgical classification of renal injury proposed by the American Association for Surgery in Trauma (AAST), there has been only limited work on the role of the AAST system as an imaging stratification. The aim was to determine the inter-rater reliability (IRR) amongst radiologists and urologists using the AAST system. METHODS: A 1-year retrospective study of consecutive patients with computed tomography (CT) evidence of renal trauma managed at a Level 1 trauma center. Three radiologists and three urologists independently stratified the presentation CT findings according to the AAST renal trauma classification. Agreement between independent raters and mutually exclusive groups was determined utilizing weighted kappa coefficients. RESULTS: One hundred and one patients were included. Individual inter-observer agreements ranged from 54/101 (53.4%) to 62/101 (61.4%), with corresponding weighted kappa values from 0.61 to 0.69, constituting substantial agreement. Urologists achieved intra-disciplinary agreement in 49 cases (48.5%) and radiologists in 36 cases (35.6%). Six-reader agreement was achieved in 24 cases (23.7%). The AAST grade I injuries had the highest level of agreement, overall. CONCLUSION: The finding of substantial IRR amongst radiologists and urologists utilizing the AAST system supports continued use of the broad parameters of the AAST system, with some modification in specific categories with lower agreement.


Asunto(s)
Contusiones/clasificación , Hematoma/clasificación , Riñón/lesiones , Laceraciones/clasificación , Variaciones Dependientes del Observador , Lesiones del Sistema Vascular/clasificación , Contusiones/diagnóstico por imagen , Hematoma/diagnóstico por imagen , Humanos , Riñón/diagnóstico por imagen , Laceraciones/diagnóstico por imagen , Tomografía Computarizada Multidetector , Radiólogos , Arteria Renal/diagnóstico por imagen , Arteria Renal/lesiones , Venas Renales/diagnóstico por imagen , Venas Renales/lesiones , Reproducibilidad de los Resultados , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Índices de Gravedad del Trauma , Urólogos , Lesiones del Sistema Vascular/diagnóstico por imagen
11.
Eur Radiol ; 28(8): 3355-3361, 2018 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-29468341

RESUMEN

OBJECTIVES: Endovascular renal denervation (RDN) using catheter-based radiofrequency (RF) ablation has emerged as a potential treatment option for drug-resistant hypertension. Its efficacy is currently under debate. We aimed to evaluate the capability of contrast-enhanced magnetic resonance imaging (MRI) to assess the effects of RDN on the renal arterial wall in patients presenting with drug-resistant hypertension. METHODS: Patients were included prospectively following institutional review board approval and written informed consent. Renal arteries were imaged using a two-dimensional T1-weighted TSE sequence pre- and post-administration of a gadolinium-based contrast agent, before (D0), 2 days (D2) and 6 months (M6) after RDN. Mean enhancement of the wall (mENH) and mean wall thickness (mWT) were compared across time using an ANOVA with repeated measures and post-hoc paired t-test. RESULTS: Follow-up was completed for 23 patients (median age, 57 years; 16 men). The mENH at D2 (96.3 ± 36.0 %) was significantly higher than at D0 (61.1 ± 26.3%, p < 0.001) and M6 (66.1±22.7%, p < 0.001). Similarly, mWT was significantly higher at D2 (3.1 ± 0.4 m) than at D0 (2.7 ± 0.4mm, p < 0.001) and M6 (2.9 ± 0. 5 mm, p = 0.002). CONCLUSIONS: MRI demonstrated abnormalities of the arterial wall 2 days after RDN that had resolved at 6 months. KEY POINTS: • Contrast-enhanced MRI provides anatomic evidence of renal artery RF ablation • Temperature increase related to RF ablation induces transient arterial wall inflammation • Morphological effects observed 2 days post RF ablation are not visible after 6 months.


Asunto(s)
Ablación por Catéter/efectos adversos , Hipertensión/cirugía , Complicaciones Intraoperatorias/diagnóstico , Arteria Renal/lesiones , Simpatectomía/efectos adversos , Anciano , Análisis de Varianza , Antihipertensivos/uso terapéutico , Ablación por Catéter/métodos , Resistencia a Medicamentos , Femenino , Humanos , Hipertensión/tratamiento farmacológico , Hipertensión/fisiopatología , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Simpatectomía/métodos
12.
Kidney Blood Press Res ; 43(5): 1607-1622, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30347394

RESUMEN

BACKGROUND/AIMS: This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43). METHODS: This study randomly divided male Sprague Dawley (SD) rats into an untreated control group, a sham-operated control group (sham group), an ischemia-reperfusion group (IR group), a propofol group (propofol+IR group) and a fat emulsion group (Intralipid group). The ischemia/reperfusion model was prepared through resection of the right kidney and noninvasive arterial occlusion of the left kidney. Forty-five minutes after renal ischemia-reperfusion, an automatic biochemical analyzer was employed to measure blood urea nitrogen (BUN) and serum creatinine (SCr); changes in renal tissue pathology were observed using hematoxylin and eosin (HE) staining, and the vasomotor activity of the interlobar artery was detected using a pressure mechanogram technique. The protein expression of Cx43 in renal artery cross-sections was determined through western blotting. RESULTS: The experimental study confirmed that the BUN and SCr of rats markedly increased after ischemia-reperfusion injury; additionally, we observed some coagulation necrosis and shedding of cells, some solidification of nuclear chromatin, degeneration of cytoplasmic vacuoles, high renal interstitial vascular congestion and obvious inflammatory cell infiltration, characterized by focal hemorrhages. Furthermore, the contraction activity of the renal interlobar artery greatly decreased, and the tension of the arteries in the renal lobe increased remarkably. After the gap junction blocking agents 2-APB and Gap27 were applied, the systolic velocity of blood vessels and the vascular contraction rate both decreased. In addition, the expression of Cx43 in kidney tissues increased markedly. The damage was more severe after 24 h of ischemic reperfusion than after only 4 h. However, after pretreatment with propofol, regardless of whether ischemia-reperfusion was applied for 4 h or 24 h, the previously increased expression of Cx43 decreased obviously, and all forms of renal damage were reversed. CONCLUSION: Our research suggests new ways for propofol to relieve ischemia-reperfusion injury by decreasing the abnormal expression of the gap junction protein Cx43. This study reveals a novel mechanism for the action of propofol against IRI, and we hope this finding will lead to new treatments for IRI.


Asunto(s)
Conexina 43/metabolismo , Propofol/farmacología , Arteria Renal/lesiones , Daño por Reperfusión/prevención & control , Animales , Velocidad del Flujo Sanguíneo , Conexina 43/análisis , Conexina 43/efectos de los fármacos , Conexinas , Masculino , Oligopéptidos , Propofol/uso terapéutico , Ratas , Ratas Sprague-Dawley , Arteria Renal/química , Daño por Reperfusión/tratamiento farmacológico , Daño por Reperfusión/patología , Vasoconstricción
14.
Urol Int ; 98(2): 245-248, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-25138054

RESUMEN

Hemodynamically stable patients with renal injury can be managed conservatively. Anatomy typically leads to physiologic confinement of urinomas or renal hematomas to the interfascial planes of the retroperitoneum. In the presented case there was unusual reperfusion 14 days after a successful embolization of a renal pseudoaneurysm, at this time 28 days after the initiating trauma. This article discusses the evolution, treatment options and possible underlying causes for the reperfusion of this late-onset renal pseudoaneurysm.


Asunto(s)
Aneurisma Falso/etiología , Embolización Terapéutica/efectos adversos , Embolización Terapéutica/métodos , Riñón/lesiones , Arteria Renal/lesiones , Accidentes de Tránsito , Adolescente , Servicio de Urgencia en Hospital , Hemodinámica , Humanos , Masculino , Recurrencia , Espacio Retroperitoneal , Tomografía Computarizada por Rayos X , Heridas no Penetrantes
15.
Urol Int ; 99(4): 484-486, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-26595208

RESUMEN

Pseudoaneurysm following flexible ureterorenoscopy has not been reported so far. The etiology remains unclear as high intra-renal pressure, direct laser damage and damage through stiff guidewire puncture had all been avoided. We like to share this case to make urologists aware of this unusual complication and discuss possible causes and therapeutic approaches.


Asunto(s)
Aneurisma Falso/etiología , Cálculos Renales/cirugía , Arteria Renal/lesiones , Ureteroscopía/efectos adversos , Lesiones del Sistema Vascular/etiología , Aneurisma Falso/diagnóstico por imagen , Aneurisma Falso/terapia , Angiografía , Embolización Terapéutica , Diseño de Equipo , Humanos , Cálculos Renales/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Arteria Renal/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Ureteroscopios , Ureteroscopía/instrumentación , Lesiones del Sistema Vascular/diagnóstico por imagen , Lesiones del Sistema Vascular/terapia
16.
Prog Urol ; 27(3): 190-199, 2017 Mar.
Artículo en Francés | MEDLINE | ID: mdl-28189485

RESUMEN

INTRODUCTION: The purpose was to describe the management of intraparenchymal pseudoaneurysm (PA) after blunt renal trauma in our center, and to review the cases published in the literature, in order to propose a management algorithm. MATERIALS AND METHODS: We reviewed the files of 325 patients included in a prospective database, from July, 2004, to May, 2016. A systematic review of the published cases was done with the keywords "blunt renal trauma" and "pseudoaneurysm" in Pubmed (excluding arteriovenous fistulas, open renal traumas and extraparenchymal PA) allowing us to analyze 29 extra cases. Management of these patients in our center is decribed. RESULTS: Among 325 kidney trauma patients, 160 (49.3%) had grade IV and V renal trauma. Conservative management was done in 93.2%. We noted 8 cases of PA, with an incidence of 2.5%. Four patients required angioembolization. Four patients were treated by watchful waiting, with 2 cases of spontaneous occlusion, one case of absence of regression and embolization, and one case of occult hemorrhage. All PA with a favorable outcome were less than 1cm. The mean relative renal scintigraphic function at 6 months of the kidneys requiring embolization was 71.6%. The literature review reported 29 published cases, among whom 26 required embolization, with a success rate of 84.6%. Two cases were just watched, but one was finally embolized in the absence of regression. CONCLUSION: Pseudoneurysm formation after blunt renal trauma is a rare complication (2.5%). In case of clinical symptoms or hemodynamic instability, embolization allows a good renal preservation. Watchful waiting seems to be an option in asymptomatic cases with a PA less than 1cm. LEVEL OF EVIDENCE: 5.


Asunto(s)
Aneurisma Falso/terapia , Riñón/lesiones , Arteria Renal/lesiones , Venas Renales/lesiones , Heridas no Penetrantes/complicaciones , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Aneurisma Falso/diagnóstico , Aneurisma Falso/etiología , Niño , Embolización Terapéutica , Femenino , Hematuria/etiología , Hemorragia/etiología , Humanos , Masculino , Persona de Mediana Edad , Nefrectomía , Remisión Espontánea , Estudios Retrospectivos , Espera Vigilante , Adulto Joven
17.
Radiographics ; 36(2): 580-95, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26871987

RESUMEN

Renal arteriovenous (AV) shunt, a rare pathologic condition, is divided into two categories, traumatic and nontraumatic, and can cause massive hematuria, retroperitoneal hemorrhage, pain, and high-output heart failure. Although transcatheter embolization is a less-invasive and effective treatment option, it has a potential risk of complications, including renal infarction and pulmonary embolism, and a potential risk of recanalization. The successful embolization of renal AV shunt requires a complete occlusion of the shunted vessel while preventing the migration of embolic materials and preserving normal renal arterial branches, which depends on the selection of adequate techniques and embolic materials for individual cases, based on the etiology and imaging angioarchitecture of the renal AV shunts. A classification of AV malformations in the extremities and body trunk could precisely correspond with the angioarchitecture of the nontraumatic renal AV shunts. The selection of techniques and choice of adequate embolic materials such as coils, vascular plugs, and liquid materials are determined on the basis of cause (eg, traumatic vs nontraumatic), the classification, and some other aspects of the angioarchitecture of renal AV shunts, including the flow and size of the fistulas, multiplicity of the feeders, and endovascular accessibility to the target lesions. Computed tomographic angiography and selective digital subtraction angiography can provide precise information about the angioarchitecture of renal AV shunts before treatment. Color Doppler ultrasonography and time-resolved three-dimensional contrast-enhanced magnetic resonance angiography represent useful tools for screening and follow-up examinations of renal AV shunts after embolization. In this article, the classifications, imaging features, and an endovascular treatment strategy based on the angioarchitecture of renal AV shunts are described.


Asunto(s)
Fístula Arteriovenosa/diagnóstico por imagen , Embolización Terapéutica/métodos , Arteria Renal/anomalías , Venas Renales/anomalías , Aneurisma/diagnóstico por imagen , Aneurisma/etiología , Angiografía de Substracción Digital/métodos , Fístula Arteriovenosa/clasificación , Fístula Arteriovenosa/terapia , Biopsia/efectos adversos , Cateterismo , Embolización Terapéutica/instrumentación , Enbucrilato , Procedimientos Endovasculares/métodos , Humanos , Complicaciones Intraoperatorias/diagnóstico por imagen , Riñón/irrigación sanguínea , Riñón/patología , Angiografía por Resonancia Magnética/métodos , Tomografía Computarizada Multidetector/métodos , Arteria Renal/diagnóstico por imagen , Arteria Renal/lesiones , Venas Renales/diagnóstico por imagen , Venas Renales/lesiones , Ultrasonografía Doppler en Color/métodos
18.
Isr Med Assoc J ; 18(11): 665-668, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-28466615

RESUMEN

BACKGROUND: Trauma is the leading cause of childhood morbidity and mortality. Abdominal bleeding is one of the common causes of mortality due to trauma. Angiography and embolization are well recognized as the primary treatments in certain cases of acute traumatic hemorrhage in adults; however, evidence is lacking in the pediatric population. OBJECTIVES: To assess the safety and efficacy of transcatheter arterial embolization (TAE) for blunt and penetrating abdominal and pelvic trauma in the pediatric age group. METHODS: Three children with blunt abdominal trauma and one child with iatrogenic renal injury (age 4-13 years) were managed with TAE for lacerated liver (one patient), pelvic fractures (one patient) and renal injuries (two patients). The first two patients, victims of road accidents, had multisystem injuries and were treated by emergency embolization after fluid resuscitation in the Emergency Department (ED). The other two patients had renal injuries: a 4 year old boy with blunt abdominal trauma was diagnosed on initial computed tomography with an unexpected Wilms tumor and was treated with embolization 1 day after admission due to hemodynamic deterioration caused by active arterial tumor bleeding. The following day he underwent successful nephrectomy. The other patient was 13 year old boy with nephrotic syndrome who underwent renal biopsy and developed hemodynamic instability. After fluid resuscitation, he underwent an initial negative angiography, but second-look angiography the following day revealed active bleeding from an aberrant renal artery, which was then successfully embolized. RESULTS: In all four patients, TAE was diagnostic as well as therapeutic, and no child required surgical intervention for control of bleeding. CONCLUSIONS: We propose that emergency transcatheter angiography and arterial embolization be considered following resuscitation in the ED as initial treatment in children with ongoing bleeding after blunt abdominal trauma or iatrogenic renal injury. Implementation of this policy demands availability and cooperation of the interventional radiology services.


Asunto(s)
Traumatismos Abdominales/terapia , Angiografía/métodos , Embolización Terapéutica/métodos , Heridas no Penetrantes/terapia , Heridas Penetrantes/terapia , Traumatismos Abdominales/diagnóstico , Adolescente , Niño , Preescolar , Servicio de Urgencia en Hospital , Femenino , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/etiología , Hemorragia Gastrointestinal/terapia , Humanos , Masculino , Arteria Renal/lesiones , Tomografía Computarizada por Rayos X , Heridas no Penetrantes/diagnóstico , Heridas Penetrantes/diagnóstico
19.
Int Braz J Urol ; 42(4): 845-7, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27564300

RESUMEN

A 35-year-old female patient presented with swelling pain at left waist for 1 month. Left renal pelvis stones were found and standard percutaneous nephrolithotomy was successfully performed. Two weeks later, the patient suddenly suffered massive bleeding presented with gross hematuria. Rupture of ectopic renal artery pseudoaneurysm was identified by computed tomography and angiography of the renal artery. Emergency selective angioembolization of one branch of the artery was performed. To our knowledge, this is the first report of ruptured ectopic renal arterial pseudoaneurysm.


Asunto(s)
Aneurisma Falso/diagnóstico por imagen , Nefrostomía Percutánea/efectos adversos , Arteria Renal/lesiones , Adulto , Embolización Terapéutica , Femenino , Humanos , Cálculos Renales/cirugía , Litotricia/efectos adversos , Hemorragia Posoperatoria/etiología , Arteria Renal/diagnóstico por imagen , Rotura Espontánea/diagnóstico por imagen , Tomografía Computarizada por Rayos X
20.
Acta Chir Orthop Traumatol Cech ; 83(4): 274-278, 2016.
Artículo en Checo | MEDLINE | ID: mdl-28026729

RESUMEN

Renal artery thrombosis is a rare complication of blunt abdominal injury. It occurs most frequently in car accidents in which sudden deceleration results in multiple internal injuries. Renal artery occlusion occurs rarely as an isolated blunt trauma. This report presents a case of traumatic occlusion of the left renal artery with complete ischaemia of the left kidney in a haemodynamically stable girl who suffered multiple seat-belt injuries in a car crash. Ambiguous findings on a CT scan of the abdominal cavity indicated surgical inspection of the abdomen and, since the injury-to-surgery interval was short, an attempt at revascularisation of the left kidney was made. This was performed using laparotomy through a lateral left-side incision, as an uncommon approach to the injured organs. A seat-belt fracture of the L2/3 spine was stabilised at secondstage surgery. Key words: renal artery thrombosis, seat-belt fracture of the lumbar spine.


Asunto(s)
Arteria Renal/lesiones , Cinturones de Seguridad/efectos adversos , Trombosis/etiología , Accidentes de Tránsito , Femenino , Humanos , Riñón/irrigación sanguínea , Enfermedades Renales , Laparotomía , Traumatismo Múltiple/complicaciones , Arteria Renal/cirugía , Trombosis/cirugía , Resultado del Tratamiento
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