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1.
Cell ; 176(5): 1222-1237.e22, 2019 02 21.
Artículo en Inglés | MEDLINE | ID: mdl-30712875

RESUMEN

High-acuity vision in primates, including humans, is mediated by a small central retinal region called the fovea. As more accessible organisms lack a fovea, its specialized function and its dysfunction in ocular diseases remain poorly understood. We used 165,000 single-cell RNA-seq profiles to generate comprehensive cellular taxonomies of macaque fovea and peripheral retina. More than 80% of >60 cell types match between the two regions but exhibit substantial differences in proportions and gene expression, some of which we relate to functional differences. Comparison of macaque retinal types with those of mice reveals that interneuron types are tightly conserved. In contrast, projection neuron types and programs diverge, despite exhibiting conserved transcription factor codes. Key macaque types are conserved in humans, allowing mapping of cell-type and region-specific expression of >190 genes associated with 7 human retinal diseases. Our work provides a framework for comparative single-cell analysis across tissue regions and species.


Asunto(s)
Fóvea Central/fisiología , Primates/fisiología , Retina/fisiología , Anciano , Animales , Callithrix , Femenino , Humanos , Macaca , Masculino , Retina/anatomía & histología , Células Ganglionares de la Retina/metabolismo
2.
Cell ; 168(3): 413-426.e12, 2017 01 26.
Artículo en Inglés | MEDLINE | ID: mdl-28129540

RESUMEN

The fovea is a specialized region of the retina that dominates the visual perception of primates by providing high chromatic and spatial acuity. While the foveal and peripheral retina share a similar core circuit architecture, they exhibit profound functional differences whose mechanisms are unknown. Using intracellular recordings and structure-function analyses, we examined the cellular and synaptic underpinnings of the primate fovea. Compared to peripheral vision, the fovea displays decreased sensitivity to rapid variations in light inputs; this difference is reflected in the responses of ganglion cells, the output cells of the retina. Surprisingly, and unlike in the periphery, synaptic inhibition minimally shaped the responses of foveal midget ganglion cells. This difference in inhibition cannot however, explain the differences in the temporal sensitivity of foveal and peripheral midget ganglion cells. Instead, foveal cone photoreceptors themselves exhibited slower light responses than peripheral cones, unexpectedly linking cone signals to perceptual sensitivity.


Asunto(s)
Fóvea Central/fisiología , Macaca/fisiología , Células Fotorreceptoras Retinianas Conos/fisiología , Percepción Visual , Animales , Cinética , Células Fotorreceptoras de Vertebrados/fisiología , Células Ganglionares de la Retina/fisiología , Sinapsis
3.
Proc Natl Acad Sci U S A ; 121(37): e2408067121, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39226351

RESUMEN

Humans explore visual scenes by alternating short fixations with saccades directing the fovea to points of interest. During fixation, the visual system not only examines the foveal stimulus at high resolution, but it also processes the extrafoveal input to plan the next saccade. Although foveal analysis and peripheral selection occur in parallel, little is known about the temporal dynamics of foveal and peripheral processing upon saccade landing, during fixation. Here we investigate whether the ability to localize changes across the visual field differs depending on when the change occurs during fixation, and on whether the change localization involves foveal, extrafoveal processing, or both. Our findings reveal that the ability to localize changes in peripheral areas of the visual field improves as a function of time after fixation onset, whereas localization accuracy for foveal stimuli remains approximately constant. Importantly, this pattern holds regardless of whether individuals monitor only foveal or peripheral stimuli, or both simultaneously. Altogether, these results show that the visual system is more attuned to the foveal input early on during fixation, whereas change localization for peripheral stimuli progressively improves throughout fixation, possibly as a consequence of an increased readiness to plan the next saccade.


Asunto(s)
Fijación Ocular , Fóvea Central , Movimientos Sacádicos , Campos Visuales , Humanos , Fijación Ocular/fisiología , Fóvea Central/fisiología , Movimientos Sacádicos/fisiología , Masculino , Femenino , Adulto , Campos Visuales/fisiología , Adulto Joven , Estimulación Luminosa/métodos , Percepción Visual/fisiología
4.
Proc Natl Acad Sci U S A ; 121(16): e2313820121, 2024 Apr 16.
Artículo en Inglés | MEDLINE | ID: mdl-38598343

RESUMEN

In primates, high-acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal maturation. However, the extent of cellular similarity across anthropoid foveas and the molecular underpinnings of foveal maturation remain unclear. Here, we used high-throughput single-cell RNA sequencing to profile retinal cells of the common marmoset (Callithrix jacchus), an early divergent in anthropoid evolution from humans, apes, and macaques. We generated atlases of the marmoset fovea and peripheral retina for both neonates and adults. Our comparative analysis revealed that marmosets share almost all their foveal types with both humans and macaques, highlighting a conserved cellular structure among primate foveas. Furthermore, by tracing the developmental trajectory of cell types in the foveal and peripheral retina, we found distinct maturation paths for each. In-depth analysis of gene expression differences demonstrated that cone photoreceptors and Müller glia (MG), among others, show the greatest molecular divergence between these two regions. Utilizing single-cell ATAC-seq and gene-regulatory network inference, we uncovered distinct transcriptional regulations differentiating foveal cones from their peripheral counterparts. Further analysis of predicted ligand-receptor interactions suggested a potential role for MG in supporting the maturation of foveal cones. Together, these results provide valuable insights into foveal development, structure, and evolution.


Asunto(s)
Callithrix , Retina , Humanos , Animales , Recién Nacido , Callithrix/anatomía & histología , Retina/metabolismo , Fóvea Central/fisiología , Células Fotorreceptoras Retinianas Conos , Macaca , Mamíferos
5.
Proc Natl Acad Sci U S A ; 121(36): e2405138121, 2024 Sep 03.
Artículo en Inglés | MEDLINE | ID: mdl-39190352

RESUMEN

The neural pathways that start human color vision begin in the complex synaptic network of the foveal retina where signals originating in long (L), middle (M), and short (S) wavelength-sensitive cone photoreceptor types are compared through antagonistic interactions, referred to as opponency. In nonhuman primates, two cone opponent pathways are well established: an L vs. M cone circuit linked to the midget ganglion cell type, often called the red-green pathway, and an S vs. L + M cone circuit linked to the small bistratified ganglion cell type, often called the blue-yellow pathway. These pathways have been taken to correspond in human vision to cardinal directions in a trichromatic color space, providing the parallel inputs to higher-level color processing. Yet linking cone opponency in the nonhuman primate retina to color mechanisms in human vision has proven particularly difficult. Here, we apply connectomic reconstruction to the human foveal retina to trace parallel excitatory synaptic outputs from the S-ON (or "blue-cone") bipolar cell to the small bistratified cell and two additional ganglion cell types: a large bistratified ganglion cell and a subpopulation of ON-midget ganglion cells, whose synaptic connections suggest a significant and unique role in color vision. These two ganglion cell types are postsynaptic to both S-ON and L vs. M opponent midget bipolar cells and thus define excitatory pathways in the foveal retina that merge the cardinal red-green and blue-yellow circuits, with the potential for trichromatic cone opponency at the first stage of human vision.


Asunto(s)
Percepción de Color , Visión de Colores , Fóvea Central , Células Fotorreceptoras Retinianas Conos , Células Ganglionares de la Retina , Humanos , Fóvea Central/fisiología , Células Fotorreceptoras Retinianas Conos/fisiología , Células Fotorreceptoras Retinianas Conos/metabolismo , Visión de Colores/fisiología , Células Ganglionares de la Retina/fisiología , Percepción de Color/fisiología , Células Bipolares de la Retina/fisiología , Células Bipolares de la Retina/metabolismo , Retina/fisiología , Masculino , Femenino , Adulto , Conectoma , Vías Visuales/fisiología
6.
Proc Natl Acad Sci U S A ; 121(37): e2413104121, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39231211

RESUMEN

The retinal fovea in human and nonhuman primates is essential for high acuity and color vision. Within the fovea lies specialized circuitry in which signals from a single cone photoreceptor are largely conveyed to one ON and one OFF type midget bipolar cell (MBC), which in turn connect to a single ON or OFF midget ganglion cell (MGC), respectively. Restoring foveal vision requires not only photoreceptor replacement but also appropriate reconnection with surviving ON and OFF MBCs and MGCs. However, our current understanding of the effects of cone loss on the remaining foveal midget pathway is limited. We thus used serial block-face electron microscopy to determine the degree of plasticity and potential remodeling of this pathway in adult Macaca fascicularis several months after acute photoreceptor loss upon photocoagulation. We reconstructed MBC structure and connectivity within and adjacent to the region of cone loss. We found that MBC dendrites within the scotoma retracted and failed to reach surviving cones to form new connections. However, both surviving cones and ON and OFF MBC dendrites at the scotoma border exhibited remodeling, suggesting that these neurons can demonstrate plasticity and rewiring at maturity. At six months postlesion, disconnected OFF MBCs clearly lost output ribbon synapses with their postsynaptic partners, whereas the majority of ON MBCs maintained their axonal ribbon numbers, suggesting differential timing or extent in ON and OFF midget circuit remodeling after cone loss. Our findings raise rewiring considerations for cell replacement approaches in the restoration of foveal vision.


Asunto(s)
Fóvea Central , Macaca fascicularis , Células Bipolares de la Retina , Células Fotorreceptoras Retinianas Conos , Animales , Células Fotorreceptoras Retinianas Conos/metabolismo , Células Fotorreceptoras Retinianas Conos/patología , Células Bipolares de la Retina/metabolismo , Células Bipolares de la Retina/fisiología , Células Ganglionares de la Retina/fisiología , Células Ganglionares de la Retina/patología , Plasticidad Neuronal/fisiología , Dendritas/fisiología , Vías Visuales , Masculino
7.
Bioessays ; 46(1): e2300054, 2024 01.
Artículo en Inglés | MEDLINE | ID: mdl-38037292

RESUMEN

The human fovea is known for its distinctive pit-like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta-analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development.


Asunto(s)
Fóvea Central , Retina , Humanos , Fóvea Central/fisiología , Células Fotorreceptoras
8.
J Neurosci ; 44(12)2024 Mar 20.
Artículo en Inglés | MEDLINE | ID: mdl-38316562

RESUMEN

With every saccadic eye movement, humans bring new information into their fovea to be processed with high visual acuity. Notably, perception is enhanced already before a relevant item is foveated: During saccade preparation, presaccadic attention shifts to the upcoming fixation location, which can be measured via behavioral correlates such as enhanced visual performance or modulations of sensory feature tuning. The coupling between saccadic eye movements and attention is assumed to be robust and mandatory and considered a mechanism facilitating the integration of pre- and postsaccadic information. However, until recently it had not been investigated as a function of saccade direction. Here, we measured contrast response functions during fixation and saccade preparation in male and female observers and found that the pronounced response gain benefit typically elicited by presaccadic attention is selectively lacking before upward saccades at the group level-some observers even showed a cost. Individual observer's sensitivity before upward saccades was negatively related to their amount of surface area in primary visual cortex representing the saccade target, suggesting a potential compensatory mechanism that optimizes the use of the limited neural resources processing the upper vertical meridian. Our results raise the question of how perceptual continuity is achieved and how upward saccades can be accurately targeted despite the lack of-theoretically required-presaccadic attention.


Asunto(s)
Movimientos Oculares , Movimientos Sacádicos , Masculino , Femenino , Humanos , Atención/fisiología , Fóvea Central , Percepción Visual/fisiología , Estimulación Luminosa
9.
J Neurosci ; 44(18)2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38548340

RESUMEN

A long-standing question in vision science is how the three cone photoreceptor types-long (L), medium (M), and short (S) wavelength sensitive-combine to generate our perception of color. Hue perception can be described along two opponent axes: red-green and blue-yellow. Psychophysical measurements of color appearance indicate that the cone inputs to the red-green and blue-yellow opponent axes are M vs. L + S and L vs. M + S, respectively. However, the "cardinal directions of color space" revealed by psychophysical measurements of color detection thresholds following adaptation are L vs. M and S vs. L + M. These cardinal directions match the most common cone-opponent retinal ganglion cells (RGCs) in the primate retina. Accordingly, the cone opponency necessary for color appearance is thought to be established in the cortex. While neurons with the appropriate M vs. L + S and L vs. M + S opponency have been reported in the retina and lateral geniculate nucleus, their existence continues to be debated. Resolving this long-standing debate is necessary because a complete account of the cone opponency in the retinal output is critical for understanding how downstream neural circuits process color. Here, we performed adaptive optics calcium imaging to noninvasively measure foveal RGC light responses in the living Macaca fascicularis eye. We confirm the presence of L vs. M + S and M vs. L + S neurons with noncardinal cone opponency and demonstrate that cone-opponent signals in the retinal output are more diverse than classically thought.


Asunto(s)
Percepción de Color , Fóvea Central , Células Fotorreceptoras Retinianas Conos , Células Ganglionares de la Retina , Animales , Células Ganglionares de la Retina/fisiología , Células Fotorreceptoras Retinianas Conos/fisiología , Fóvea Central/fisiología , Percepción de Color/fisiología , Estimulación Luminosa/métodos , Masculino , Femenino , Macaca fascicularis
10.
J Neurosci ; 44(3)2024 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-38050093

RESUMEN

Human visual performance for basic visual dimensions (e.g., contrast sensitivity and acuity) peaks at the fovea and decreases with eccentricity. The eccentricity effect is related to the larger visual cortical surface area corresponding to the fovea, but it is unknown if differential feature tuning contributes to this eccentricity effect. Here, we investigated two system-level computations underlying the eccentricity effect: featural representation (tuning) and internal noise. Observers (both sexes) detected a Gabor embedded in filtered white noise which appeared at the fovea or one of four perifoveal locations. We used psychophysical reverse correlation to estimate the weights assigned by the visual system to a range of orientations and spatial frequencies (SFs) in noisy stimuli, which are conventionally interpreted as perceptual sensitivity to the corresponding features. We found higher sensitivity to task-relevant orientations and SFs at the fovea than that at the perifovea, and no difference in selectivity for either orientation or SF. Concurrently, we measured response consistency using a double-pass method, which allowed us to infer the level of internal noise by implementing a noisy observer model. We found lower internal noise at the fovea than that at the perifovea. Finally, individual variability in contrast sensitivity correlated with sensitivity to and selectivity for task-relevant features as well as with internal noise. Moreover, the behavioral eccentricity effect mainly reflects the foveal advantage in orientation sensitivity compared with other computations. These findings suggest that the eccentricity effect stems from a better representation of task-relevant features and lower internal noise at the fovea than that at the perifovea.


Asunto(s)
Sensibilidad de Contraste , Corteza Visual , Masculino , Femenino , Humanos , Orientación/fisiología , Corteza Visual/fisiología , Fóvea Central/fisiología , Ruido
11.
Dev Biol ; 511: 39-52, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38548147

RESUMEN

The fovea is a small region within the central retina that is responsible for our high acuity daylight vision. Chickens also have a high acuity area (HAA), and are one of the few species that enables studies of the mechanisms of HAA development, due to accessible embryonic tissue and methods to readily perturb gene expression. To enable such studies, we characterized the development of the chick HAA using single molecule fluorescent in situ hybridization (smFISH), along with more classical methods. We found that Fgf8 provides a molecular marker for the HAA throughout development and into adult stages, allowing studies of the cellular composition of this area over time. The radial dimension of the ganglion cell layer (GCL) was seen to be the greatest at the HAA throughout development, beginning during the period of neurogenesis, suggesting that genesis, rather than cell death, creates a higher level of retinal ganglion cells (RGCs) in this area. In contrast, the HAA acquired its characteristic high density of cone photoreceptors post-hatching, which is well after the period of neurogenesis. We also confirmed that rod photoreceptors are not present in the HAA. Analyses of cell death in the developing photoreceptor layer, where rods would reside, did not show apoptotic cells, suggesting that lack of genesis, rather than death, created the "rod-free zone" (RFZ). Quantification of each cone photoreceptor subtype showed an ordered mosaic of most cone subtypes. The changes in cellular densities and cell subtypes between the developing and mature HAA provide some answers to the overarching strategy used by the retina to create this area and provide a framework for future studies of the mechanisms underlying its formation.


Asunto(s)
Retina , Células Ganglionares de la Retina , Animales , Embrión de Pollo , Células Ganglionares de la Retina/citología , Retina/embriología , Células Fotorreceptoras Retinianas Conos/metabolismo , Pollos , Neurogénesis/fisiología , Factor 8 de Crecimiento de Fibroblastos/metabolismo , Factor 8 de Crecimiento de Fibroblastos/genética , Hibridación Fluorescente in Situ , Fóvea Central/embriología , Agudeza Visual , Células Fotorreceptoras Retinianas Bastones/metabolismo , Células Fotorreceptoras Retinianas Bastones/citología , Regulación del Desarrollo de la Expresión Génica
12.
Proc Natl Acad Sci U S A ; 119(24): e2121860119, 2022 06 14.
Artículo en Inglés | MEDLINE | ID: mdl-35675430

RESUMEN

The foveal visual image region provides the human visual system with the highest acuity. However, it is unclear whether such a high fidelity representational advantage is maintained when foveal image locations are committed to short-term memory. Here, we describe a paradoxically large distortion in foveal target location recall by humans. We briefly presented small, but high contrast, points of light at eccentricities ranging from 0.1 to 12°, while subjects maintained their line of sight on a stable target. After a brief memory period, the subjects indicated the remembered target locations via computer controlled cursors. The biggest localization errors, in terms of both directional deviations and amplitude percentage overshoots or undershoots, occurred for the most foveal targets, and such distortions were still present, albeit with qualitatively different patterns, when subjects shifted their gaze to indicate the remembered target locations. Foveal visual images are severely distorted in short-term memory.


Asunto(s)
Fóvea Central , Memoria a Corto Plazo , Recuerdo Mental , Fóvea Central/fisiología , Humanos , Percepción Visual
13.
J Cogn Neurosci ; 36(9): 1807-1826, 2024 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-38940724

RESUMEN

Visual working memory is believed to rely on top-down attentional mechanisms that sustain active sensory representations in early visual cortex, a mechanism referred to as sensory recruitment. However, both bottom-up sensory input and top-down attentional modulations thereof appear to prioritize the fovea over the periphery, such that initially peripheral percepts may even be assimilated by foveal processes. This raises the question whether and how visual working memory differs for central and peripheral input. To address this, we conducted a delayed orientation recall task in which an orientation was presented either at the center of the screen or at 15° eccentricity to the left or right. Response accuracy, EEG activity, and gaze position were recorded from 30 participants. Accuracy was slightly but significantly higher for foveal versus peripheral memories. Decoding of EEG recordings revealed a clear dissociation between early sensory and later maintenance signals. Although sensory signals were clearly decodable for foveal stimuli, they were not for peripheral input. In contrast, maintenance signals were equally decodable for both foveal and peripheral memories, suggesting comparable top-down components regardless of eccentricity. Moreover, although memory representations were initially spatially specific and reflected in voltage fluctuations, later during the maintenance period, they generalized across locations, as emerged in alpha oscillations, thus revealing a dynamic transformation within memory from separate sensory traces to what we propose are common output-related codes. Furthermore, the combined absence of reliable decoding of sensory signals and robust presence of maintenance decoding indicates that storage activity patterns as measured by EEG reflect signals beyond primary visual cortex. We discuss the implications for the sensory recruitment hypothesis.


Asunto(s)
Electroencefalografía , Fóvea Central , Memoria a Corto Plazo , Humanos , Masculino , Femenino , Adulto Joven , Adulto , Memoria a Corto Plazo/fisiología , Fóvea Central/fisiología , Percepción Visual/fisiología , Atención/fisiología , Recuerdo Mental/fisiología
14.
Proc Biol Sci ; 291(2018): 20232867, 2024 Mar 13.
Artículo en Inglés | MEDLINE | ID: mdl-38471562

RESUMEN

A delayed foveal mask affects perception of peripheral stimuli. The effect is determined by the timing of the mask and by the similarity with the peripheral stimulus. A congruent mask enhances performance, while an incongruent one impairs it. It is hypothesized that foveal masks disrupt a feedback mechanism reaching the foveal cortex. This mechanism could be part of a broader circuit associated with mental imagery, but this hypothesis has not as yet been tested. We investigated the link between mental imagery and foveal feedback. We tested the relationship between performance fluctuations caused by the foveal mask-measured in terms of discriminability (d') and criterion (C)-and the scores from two questionnaires designed to assess mental imagery vividness (VVIQ) and another exploring object imagery, spatial imagery and verbal cognitive styles (OSIVQ). Contrary to our hypotheses, no significant correlations were found between VVIQ and the mask's impact on d' and C. Neither the object nor spatial subscales of OSIVQ correlated with the mask's impact. In conclusion, our findings do not substantiate the existence of a link between foveal feedback and mental imagery. Further investigation is needed to determine whether mask interference might occur with more implicit measures of imagery.


Asunto(s)
Imaginación , Percepción Visual , Fóvea Central , Encuestas y Cuestionarios , Personalidad
15.
Mol Vis ; 30: 58-66, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38601016

RESUMEN

Purpose: Pathogenic variants in North Carolina macular dystrophy (NCMD) have rarely been reported in the East Asian population. Herein, we reported novel variants of NCMD in 2 Korean families. Methods: The regions associated with NCMD were analyzed with genome sequencing, and variants were filtered based on the minor allele frequency (0.5%) and heterozygosity. Non-coding variants were functionally annotated using multiple computational tools. Results: We identified two rare novel variants, chr6:g.99,598,914T>C (hg38; V17) and chr6:g.99,598,926G>A (hg38; V18) upstream of PRDM13 in families A and B, respectively. In Family 1, Grade 2 NCMD and a best-corrected visual acuity of 20/25 and 20/200 in the right and left eyes, respectively, were observed. In Family B, all affected individuals had Grade 1 NCMD with characteristic confluent drusen at the fovea and a best-corrected visual acuity of 20/20 in both eyes. These two variants are 10-22 bp downstream of the reported V10 variant within the DNase1 hypersensitivity site. This site is associated with progressive bifocal chorioretinal atrophy and congenital posterior polar chorioretinal hypertrophy and lies in the putative enhancer site of PRDM13. Conclusion: We identified two novel NCMD variants in the Korean population and further validated the regulatory role of the DNase1 hypersensitivity site upstream of PRDM13.


Asunto(s)
Distrofias Hereditarias de la Córnea , Humanos , Distrofias Hereditarias de la Córnea/genética , Fóvea Central , Nucleótidos , Linaje , República de Corea
16.
Lupus ; 33(10): 1145-1147, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39031657

RESUMEN

INTRODUCTION: The association of outer foveal microdefect and LES or hydroxychloroquine use has not been established in current literature. CASE REPORT: We present the first reported case of bilateral outer foveal microdefect ina a patient with systemic lúpus erythematosus using hydroxycloroquine. DISCUSSION/CONCLUSION: While it is not possible to definitively attribute the described findings in our patient to HCQ use, it is important to be aware of the possibility that the outer foveal microdefect may be caused by this medication. Therefore, patients on chronic HCQ therapy should be informed about the risk of potential visual adverse effects, so that appropriate interventions can be implemented if necessary.


Asunto(s)
Fóvea Central , Hidroxicloroquina , Lupus Eritematoso Sistémico , Humanos , Hidroxicloroquina/efectos adversos , Hidroxicloroquina/uso terapéutico , Lupus Eritematoso Sistémico/tratamiento farmacológico , Lupus Eritematoso Sistémico/complicaciones , Fóvea Central/patología , Femenino , Antirreumáticos/efectos adversos , Antirreumáticos/uso terapéutico , Tomografía de Coherencia Óptica , Adulto , Agudeza Visual
17.
Psychophysiology ; 61(5): e14524, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38297818

RESUMEN

The depth at which parafoveal words are processed during reading is an ongoing topic of debate. Recent studies using RSVP-with-flanker paradigms have shown that implausible words within sentences elicit an N400 component while they are still in parafoveal vision, suggesting that the semantics of parafoveal words can be accessed to rapidly update the sentence representation. To study this effect in natural reading, we combined the coregistration of eye movements and EEG with the deconvolution modeling of fixation-related potentials (FRPs) to test whether semantic plausibility is processed parafoveally during Chinese sentence reading. For one target word per sentence, both its parafoveal and foveal plausibility were orthogonally manipulated using the boundary paradigm. Consistent with previous eye movement studies, we observed a delayed effect of parafoveal plausibility on fixation durations that only emerged on the foveal word. Crucially, in FRPs aligned to the pretarget fixation, a clear N400 effect emerged already based on parafoveal plausibility, with more negative voltages for implausible previews. Once participants fixated the target, we again observed an N400 effect of foveal plausibility. Interestingly, this foveal N400 was absent whenever the preview had been implausible, indicating that when a word's (im)plausibility is already processed in parafoveal vision, this information is not revised anymore upon direct fixation. Implausible words also elicited a late positive component (LPC), but exclusively when in foveal vision. Our results not only provide convergent neural and behavioral evidence for the parafoveal uptake of semantic information, but also indicate different contributions of parafoveal versus foveal information toward higher level sentence processing.


Asunto(s)
Potenciales Evocados , Lectura , Humanos , Electroencefalografía , Movimientos Oculares , Fijación Ocular , Fóvea Central , Semántica
18.
Doc Ophthalmol ; 149(1): 47-52, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38922562

RESUMEN

INTRODUCTION: Infantile nystagmus and foveal hypoplasia associated with AHR gene defects is a newly recognized and rare disorder. Our aim was to present a patient with a novel biallelic AHR pathogenic variant with electrophysiological evidence of chiasmal misrouting. MATERIALS AND METHODS: Complete ocular examination, fundus imaging, visual evoked potentials (VEP) and full-field electroretinography were performed at initial presentation. Genetic testing was performed by whole exome sequencing. RESULTS: Female patient of 6 years old presented a reduced best corrected visual acuity, an infantile nystagmus and a grade III typical foveal hypoplasia without ocular hypopigmentation. A crossed asymmetry was discovered on pattern onset/offset VEP. Genetic testing put in evidence a novel homozygous variant in AHR: c.2242del, p. (Gln748Lysfs*5). During 11-years follow-up period, BCVA gradually improved. There was no evidence of retinal degeneration. CONCLUSION: AHR gene defects could be associated with infantile nystagmus, foveal hypoplasia and chiasmal misrouting.


Asunto(s)
Electrorretinografía , Potenciales Evocados Visuales , Fóvea Central , Nistagmo Congénito , Humanos , Femenino , Fóvea Central/anomalías , Nistagmo Congénito/genética , Nistagmo Congénito/fisiopatología , Nistagmo Congénito/diagnóstico , Niño , Receptores de Hidrocarburo de Aril/genética , Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética , Agudeza Visual/fisiología , Proteínas Represoras/genética , Tomografía de Coherencia Óptica
19.
Doc Ophthalmol ; 148(1): 65-71, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38172268

RESUMEN

PURPOSE: In this study, we report a case of a young adult with X-linked juvenile retinoschisis (XLRS) with a rare pathogenic variant in the RS1 gene (c.522 + 2 T > A). METHODS: Ophthalmological evaluation, optical coherence tomography, full-field and multifocal electroretinograms and extensive genetic screening of genes related to visual loss were carried out in the participant. RESULTS: Clinical ophthalmological exams revealed a mild to moderate impairment of visual acuity. Retinal imaging showed bilateral foveal schisis, as well as normal a-wave, reduction in the b-wave amplitudes in dark- and light- adapted full-field electroretinograms, and abnormal oscillatory potentials. We found also diffuse amplitude reduction in multifocal electroretinogram arrays. A canonical splice variant was identified in the RS1 gene (c.522 + 2 T > A). CONCLUSION: A rare pathogenic variant of the RS1 gene was associated with diffuse retinal involvement (central and peripheral retina), probably in inner retina, and mild to moderate visual acuity impairment. The phenotypical characterization of rare mutations is relevant to provide information about the disease.


Asunto(s)
Electrorretinografía , Retinosquisis , Adulto Joven , Humanos , Retina/patología , Retinosquisis/diagnóstico , Retinosquisis/genética , Mutación , Fóvea Central/patología , Proteínas del Ojo/genética , Tomografía de Coherencia Óptica
20.
Graefes Arch Clin Exp Ophthalmol ; 262(7): 2101-2109, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38326629

RESUMEN

PURPOSE: To assess the relationship of optical coherence tomography (OCT) findings and progression to foveal atrophy in a cohort of eyes with extrafoveal geographic atrophy (GA) and age-related macular degeneration (AMD) at inclusion. METHODS: We retrospectively analyzed 45 participants (45 eyes) with extrafoveal GA at baseline and with 2 years of regular follow-ups. Several OCT qualitative features (i.e., presence of foveal flat pigment epithelium detachment with a thin double layer sign [DLS] and reticular pseudodrusen, GA focality) and quantitative measurements (outer retinal layer thickness, retinal pigment epithelium [RPE] to Bruch's membrane [BM] volume, minimum distance from the central foveal circle, and untransformed GA lesion size area) were assessed at baseline. Logistic regression analyses were carried out to identify independent significant predictors and compute odds ratios (ORs) for the risk of the development of atrophy. RESULTS: At month 24, 26 eyes (57.8%) developed atrophy in the foveal central circle, while 11 eyes (24.4%) developed atrophy in the foveal central point. Significant independent predictive features for the development of atrophy in the foveal central circle included foveal outer retinal thickness (OR, 0.867; p = 0.015), minimum distance from the foveal central circle (OR, 0.992; p = 0.022), and foveal thin DLS (OR, 0.044; p = 0.036). The only independent predictive feature for the development of atrophy in the foveal central point was the presence of foveal thin DLS (OR, 0.138; p = 0.017). CONCLUSIONS: We identified OCT risk factors for 2-year foveal atrophy in eyes with untreated extrafoveal GA at baseline.


Asunto(s)
Progresión de la Enfermedad , Angiografía con Fluoresceína , Fóvea Central , Atrofia Geográfica , Epitelio Pigmentado de la Retina , Tomografía de Coherencia Óptica , Agudeza Visual , Humanos , Tomografía de Coherencia Óptica/métodos , Fóvea Central/patología , Femenino , Atrofia Geográfica/diagnóstico , Atrofia Geográfica/etiología , Masculino , Estudios Retrospectivos , Factores de Riesgo , Anciano , Estudios de Seguimiento , Epitelio Pigmentado de la Retina/patología , Angiografía con Fluoresceína/métodos , Fondo de Ojo , Anciano de 80 o más Años , Factores de Tiempo , Degeneración Macular/diagnóstico , Persona de Mediana Edad
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