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Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome / Efeitos da melatonina sobre o tecido pulmonar no modelo experimental de Síndrome Hepatopulmonar

Bosco, Adriane Dal; Schedler, Filipe Boeira; Colares, Josieli Raskopf; Schemitt, Elisângela Gonçalves; Hartmann, Renata Minuzzo; Forgiarini Junior, Luiz Alberto; Dias, Alexandre Simões; Marroni, Norma Possa.
J. bras. pneumol; 45(3): e20170164, 2019. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1012550
ABSTRACT

Objective:

To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL).

Methods:

Sixteen male Wistar rats, divided into four Sham groups BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung / body weight ratio (%) were evaluated.

Results:

When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups.

Conclusion:

The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.
Biblioteca responsable: BR1.1