Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Chapadense, Francesca; Machado, Ricardo Luiz Dantas; Ventura, Ana Maria Revorêdo da Silva; Áreas, André; Machado, Renato Beilner; Viana, Giselle Rachid; Zalis, Mariano Gustavo; Castro, Ana Maria de; Cravo, Pedro.
Rev. Soc. Bras. Med. Trop;
52: e20180225, 2019. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-1041579
Abstract INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance.
METHODS:
We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil.RESULTS:
We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples.CONCLUSIONS:
Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.
Biblioteca responsable:
BR1.1
Texto completo