HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
Grotto, Rejane Maria Tommasini; Santos, Francielle Martins; Picelli, Natália; Silva, Giovanni Faria; Ferrasi, Adriana Camargo; Sarnighausen, Valéria Cristina Rodrigues; Pardini, Maria Inês de Moura Campos.
Rev. Soc. Bras. Med. Trop;
52: e20170427, 2019. tab
Artículo
en Inglés
| LILACS | ID: biblio-1041583
Abstract
INTRODUCTION:
HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.METHODS:
PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.RESULTS:
There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.CONCLUSIONS:
The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
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