Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential
Bretas, Ana Carolina Oliveira; Souza, Thiago Belarmino de; Borelli, Beatriz; Johan, Suzana; Alves, Ricardo José.
Braz. J. Pharm. Sci. (Online);
56: e17652, 2020. graf
Artículo
en Inglés
| LILACS-Express
| ID: biblio-1089219
Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors.
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