CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
Costa, Germano Carneiro; Programa de Pós-Graduação em Infectologia e Medicina TropicalRocha, Manoel Otávio da Costa; Souza, Paulo Eduardo Alencar de; Laboratório de Biologia das Interações CelularesMelo, Diego Felipe SA; Laboratório de Biologia das Interações CelularesMoreira, Paula Rocha; Gollob, Kenneth John; Programa de Pós-Graduação em Infectologia e Medicina TropicalNunes, Maria do Carmo Pereira; Laboratório de Biologia das Interações CelularesDutra, Walderez Ornelas.
Mem. Inst. Oswaldo Cruz;
115: e200110, 2020. tab, graf
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| LILACS, SES-SP | ID: biblio-1135276
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes.
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