The availability of Trypanosomatid genomic data in public databases has opened myriad experimental possibilities that have contributed to a more comprehensive
understanding of the
biology of these
parasites and their interactions with hosts. In this
review, after brief remarks on the
history of the
Trypanosoma cruzi and
Leishmania genome initiatives, we present an overview of the relevant contributions of
genomics,
transcriptomics and
functional genomics, discussing the primary obstacles, challenges, relevant
achievements and
future perspectives of these
technologies.