Effect of ethanolic extracts from Piperaceae leaves on the reduction of skin necrosis and wound healing in an animal model of degloving injuries
Acta cir. bras
; 38: e387223, 2023. tab, graf, ilus
Article
en En
| LILACS, VETINDEX
| ID: biblio-1519883
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
Purpose:
To assess the effect of the ethanolic extract of the leaves of three species of plants from the Piperaceae family on reducing necrosis and enhancing wound healing in an animal model of degloving injuries.Methods:
The animals were divided into six groups, each consisting of six animals sham, negative control, EEPA (Piper amalago ethanolic extract), EEPG (Piper glabratum ethanolic extract), EEPV (Piper vicosanum ethanolic extract), and positive control receiving hyperbaric oxygenation. The animals underwent surgery to induce excision wounds, and the extent of cutaneous necrosis was evaluated using graphic software, while wound healing was assessed through histopathology.Results:
Skin necrosis percentage area was sham group = 62.84% 6.38; negative control group = 63.03% 4.11; P. vicosanum = 40.80% 4.76 p < 0.05; P. glabratum 32.97% 4.01 p < 0.01; P. amalago = 32.40% 4.61 p < 0.01; hyperbaric oxygenation = 33.21% 4.29 p < 0.01. All treated groups showed higher collagen deposition and less intense, plus predominantly mononuclear inflammatory infiltrate, suggesting improved healing process.Conclusions:
The three tested extracts demonstrated efficacy in reducing the extent of cutaneous necrosis caused by degloving injuries and also showed evidence of improvement in the wound healing process.Palabras clave
Texto completo:
1
Bases de datos:
LILACS
/
VETINDEX
Asunto principal:
Cicatrización de Heridas
/
Heridas y Lesiones
/
Extractos Vegetales
/
Piperaceae
/
Etanol
/
Lesiones por Desenguantamiento
/
Necrosis
Idioma:
En
Revista:
Acta cir. bras
Asunto de la revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil