Fluorescent test accurately predicts leak of ischemic colon anastomosis in rats
Moschetti, Laura; Ghezzi, Tiago Leal; Müller, Belisa Gomes; Dias, Adriano Basso; Corleta, Oly Campos.
Acta cir. bras;
32(6): 440-448, June 2017. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-886209
Abstract
Purpose:
To investigate if fluorescein fluorescent test can predict dehiscence in a model of ischemic colonic anastomosis in rats.Methods:
This experimental controlled trial randomly assigned 55 rats to four groups. Anastomoses were performed in non-ischemic colon segments (control group) and in ischemic colon segments measuring 1, 2 or 3 cm long (groups 1, 2 and 3, respectively). Fluorescein was injected and the tissues were examined under ultraviolet light. Seven days later, a second-look surgery was performed to check for the presence or absence of anastomosis dehiscence.Results:
Twenty-four rats presented anastomotic dehiscence during the second-look surgery. Reticular and nonfluorescent patterns were significantly associated with the occurrence of anastomotic dehiscence. Fluorescein fluorescence had a sensitivity of 95.8%, specificity of 89.2%, positive predictive value of 88.4%, negative predictive value of 96.2%, and accuracy of 92.3% to predict anastomotic dehiscence.Conclusion:
Fluorescein fluorescent test can accurately predict leak in a model of ischemic colonic anastomosis in rats.
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