The canonical wnt pathway in gastric carcinoma / Via canônica do wnt no carcinoma gástrico
Oliveira, Levindo Alves de; Oshima, Celina Tizuko Fujiyama; Soffner, Pedro Augusto; Silva, Marcelo de Souza; Lins, Rodrigo Rego; Malinverni, Andréa Cristina de Moraes; Waisberg, Jaques.
ABCD (São Paulo, Impr.);
32(1): e1414, 2019. tab, graf
Artículo
en Inglés
| LILACS | ID: biblio-973381
ABSTRACT
Background:
It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis.Aim:
To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma.Method:
The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc.Results:
There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren's intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables.Conclusion:
The canonical WNT pathway is involved in gastric carcinoma.
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BR1.1
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