Low applicability of the six-and-twelve score in hepatocellular carcinomatreated with drug-eluting bead transarterial chemoembolization
Pipa-Muñiz, María; Castaño-García, Andrés; Sanmartino, Susana; Mesa, Alicia; Álvarez-Navascués, Carmen; González-Diéguez, María Luisa; Cadahía-Rodrigo, Valle; Piscoya-Díaz, Mario Ernesto; Costilla-García, Serafín Marcos; Rodríguez, Manuel; Varela, María.
Rev. esp. enferm. dig;
114(1): 28-34, enero 2022. tab, graf
Artículo
en Inglés
| IBECS (España) | ID: ibc-205523
Objective:
the effectiveness of transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) dependson the selection of suitable patients. The six-and-twelve score distinguishes three groups of ideal patients with different overall survival, based on the sum of the number and size of tumors. This may impact on clinical practice and trial design. The aim of this study was to assess the reproducibility and prognostic value of the model in western patients treated with drug-eluting beads (DEB)-TACE.Methods:
an observational, retrospective, unicentric study with consecutive compensated patients treated with DEBTACE from October 2008 to October 2017. Exclusion criteria were Child-Pugh ≥ 8 and DEB-TACE used as a bridge to liver transplantation.Results:
a total of 225 consecutive HCC patients were included; BCLC-0/A, n = 131 (single nodules > 5, n = 29) andBCLC-B, n = 94. Median overall survival (OS) was 27 months (95 % CI, 23.8-30.2). OS was different between BCLC-0/A and BCLC-B 30 vs. 24 months (p = 0.03), Child-Pugh A5 vs. A6-B7 30 vs. 27 months (p = 0.003). Six-and-twelve score groups discriminated OS group 1, n = 123, 32 months (95 % CI, 27.5-63.5); group 2, n = 101, 24 months (95% CI, 19.6-28.4); and group 3, n = 1, 27 months (p = 0.024). When comparing the three scores, the six-and-twelve score showed the best discrimination power C-index, 0.603; Akaikes informationcriterion (AIC), 1.642; likelihood ratio test (LRT), 16.21.Conclusion:
The six-and-twelve score is a prognostic tool for patients with HCC treated with DEB-TACE. However, few patients were included in the third group (score > 12) and no differences were observed with BCLC, therefore applicability is limited. (AU)
Biblioteca responsable:
ES1.1
Ubicación: ES15.1 - BNCS
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