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FOXD2-AS1 acts an oncogene in esophageal squamous cell carcinoma through sponging miR-204-3p
Luo, Dongbo; Salai, Adili; Lv, Hongbo; Wang, Yang; Gao, Yunfei.
Afiliación
  • Luo, Dongbo; Affiliated Tumor Hospital of Xinjiang Medical University. Ürümqi. China
  • Salai, Adili; Affiliated Tumor Hospital of Xinjiang Medical University. Ürümqi. China
  • Lv, Hongbo; Affiliated Tumor Hospital of Xinjiang Medical University. Ürümqi. China
  • Wang, Yang; Affiliated Tumor Hospital of Xinjiang Medical University. Ürümqi. China
  • Gao, Yunfei; Affiliated Tumor Hospital of Xinjiang Medical University. Ürümqi. China
Clin. transl. oncol. (Print) ; 24(10): 1954–1963, octubre 2022.
Article en En | IBECS | ID: ibc-207951
Biblioteca responsable: ES1.1
Ubicación: ES15.1 - BNCS
ABSTRACT
Purpose: A growing number of evidences has revealed that long non-coding RNAs (lncRNAs) have vital effect in the pathogenesis of esophageal squamous cell carcinoma (ESCC). In our work, we found that lncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) was significantly increased in clinical ESCC samples and cell lines.MethodsThe biological effect of FOXD2-AS1 on EC109 and KYSE150 cells showed that the low expression of FOXD2-AS1 inhibited the proliferation through CCK8 and colony formation assays, invasion by transwell chamber test, migration abilities by wound healing assay, and enhance apoptosis rates by flow cytometry assay.ResultsThrough bioinformatics analysis and luciferase reporter assays, microRNA (miR)-204-3p was proved to be a target of FOXD2-AS1. We further confirmed that FOXD2-AS1 was the upstream inhibitor of miR-204-3p and the down-regulation of miR-204-3p reversed the repressive effects of low expression of FOXD2-AS1 on ESCC progression. In addition, inhibition of FOXD2-AS1 effectively suppressed the tumor growth.ConclusionsIn general, our results suggested that FOXD2-AS1 may be of vital therapeutic importance for the treatment of ESCC patients. (AU)
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Bases de datos: IBECS Asunto principal: Oncogenes / Neoplasias Esofágicas / Regulación Neoplásica de la Expresión Génica / Línea Celular Tumoral / Proliferación Celular / Carcinoma de Células Escamosas de Esófago Límite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Article
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Bases de datos: IBECS Asunto principal: Oncogenes / Neoplasias Esofágicas / Regulación Neoplásica de la Expresión Génica / Línea Celular Tumoral / Proliferación Celular / Carcinoma de Células Escamosas de Esófago Límite: Humans Idioma: En Revista: Clin. transl. oncol. (Print) Año: 2022 Tipo del documento: Article