Cytogenetic findings in 303 mexican patients with de novo acute myeloblastic leukemia
Arch. med. res
; 28(2): 209-14, jul. 1997. tab
Article
en En
| LILACS
| ID: lil-225216
Biblioteca responsable:
MX1.1
RESUMEN
In this report we show the chromosomal changes seen in a group of 303 Mexican patients with de novo Acute myeloblastic Leukemia (AML). Two hundred forty-two patients were diagnosed and treated at two hospitals affiliated with the Instituto Mexicano del Seguro Social (IMSS). These are the Centro Medico Nacional Siglo XXI and Centro Medico La Raza Hospitals; the remaining 61 patients were diagnosed and treated at the Hospital General de Mexico (HGM). Clonal abnormalities were detected in 75.6 percent of the patients; this result agrees with what has been reported in other large series of AML studies. The incidence of changes per hospital was similar in patients from the IMSS hospitals (72-75 percent), while an increase was seen in patients from the HGM (85.2 percent). The cromosomal changes seen in this study in order of frequency were t(15;17)[18.8 percent], t(9;22)[9.2 percent], miscellaneous chromosomal changes (mainly rearrangementa of chromosomes 1,2,3,12 y 17) [8.2 percent], abnormalities of 16q22 [7.3 percent], t(8;21)[6.3 percent], -7/del(7q)[5.6 percent], t(6;9)[5.3 percent), and abnormalities of 11q23 [4.6 percent]. We reported an increase in the indicidence of certain types of chromosomal changes seen in cases of AML, in comparison with reports from other countries. These differences must not be disregarded. We support this finding when comparing distribution of changes in the population of patients seen in the IMSS hospitals with those from the HGM; the main difference lies in the socioeconomic level
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Bases de datos:
LILACS
Asunto principal:
Cromosomas Humanos Par 15
/
Cromosomas Humanos Par 17
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Cromosoma Filadelfia
/
Leucemia Mieloide Aguda
/
Aberraciones Cromosómicas
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Deleción Cromosómica
/
México
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
/
Female
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Humans
/
Male
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Arch. med. res
Asunto de la revista:
MEDICINA
Año:
1997
Tipo del documento:
Article