(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians
Kvitko, Kátia; Nunes, Janice Corrêa de Barros; Hutz, Mara Helena.
Genet. mol. biol;
27(3): 335-336, Sept. 2004. tab
Artículo
en Inglés
| LILACS | ID: lil-366176
We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively seven repeats (A5), 0.586 and 0.80; eight repeats (A4), 0.092 and 0.06; nine repeats (A3), 0.014 and 0.01; eleven repeats (A2), 0.284 and 0.09; twelve repeats (A1), 0.021 and 0.04. In addition, one Euro-Brazilian individual had a rare allele with 13 repeats. The allelic frequencies in Euro- and Afro-Brazilians differed statistically (p < 10-3). The two samples were found to be in Hardy-Weinberg equilibrium (p = 0,828 and p = 0,995).
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BR26.1
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