MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis
Genet. mol. biol
; Genet. mol. biol;31(4): 836-838, Sept.-Dec. 2008. tab
Article
en En
| LILACS
| ID: lil-501465
Biblioteca responsable:
BR26.1
ABSTRACT
Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.
Palabras clave
Texto completo:
1
Bases de datos:
LILACS
Asunto principal:
Factor V
/
Protrombina
/
Estenosis Coronaria
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Genet. mol. biol
Asunto de la revista:
GENETICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Turquía