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A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study / Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

Miranda, Aline Silva de; Rodrigues, David Henrique; Vieira, Luciene Bruno; Lima, Cristiano Xavier; Rachid, Milene Alvarenga; Vidigal, Paula Vieira Teixeira; Gomez, Marcus Vinicius; Reis, Helton José dos; Guatimosim, Cristina; Teixeira, Antônio Lúcio.
Arq. neuropsiquiatr; 68(4): 597-602, Aug. 2010. graf, ilus
Artículo en Inglés | LILACS | ID: lil-555241

OBJECTIVE:

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA) in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in neurotransmitter release.

METHOD:

HE was induced by an intraperitoneal single dose of TAA (200 mg/kg, 600 mg/kg or 1,200 mg/kg). Behavioral symptoms were evaluated using the SHIRPA battery. Liver damage was confirmed by histopathological analysis. The glutamate release was measured using fluorimetric assay.

RESULTS:

The neuropsychiatric state, motor behavior and reflex and sensory functions were significantly altered in the group receiving 600 mg/kg of TAA. Biochemical analysis revealed an increase in the glutamate release in the cerebral cortex of HE mice.

CONCLUSION:

HE induced by 600mg/kg TAA injection in C57BL/6 mice seems to be a suitable model to investigate the pathogenesis and clinical disorders of HE.
Biblioteca responsable: BR1.1