Leishmanicidal activities of the extract from Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae / Atividade leishmanicida do extrato de Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae
Siqueira, Ezequias Pessoa de; Souza-Fagundes, Elaine Maria de; Sobral, Marcos Eduardo Guerra; Alves, Tânia Maria de Almeida; Rabello, Ana; Zani, Carlos Leomar.
Rev. bras. farmacogn;
20(3): 416-421, jun.-jul. 2010. graf, tab
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| LILACS | ID: lil-555924
Crude ethanolic extracts from Blepharocalyx salicifolius (Kunth) O. Berg, Myrtaceae, was fractioned by Gel Permeation Chromatography, using SephadexTM LH-20 gel. Sixteen fractions were obtained and were supplied to cytotoxicity in vitro assay against Leishmania (L.) amazonensis amastigota cells. It was observed eight cytotoxic fractions against Leishmania (L.) amazonensis amastigota cells at range of 19 to 29 µg.mL-1. Two of them were not citotoxic against human peripheral blood mononuclear cell, with a great potential to isolation of more selective leishmanicidal substances.
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