Cetuximab desensitization protocol in two patients with metastatic colorectal cancer after grade 3 infusion reaction to cetuximab
Appl. cancer res
; 32(3): 95-98, 2012. tab
Article
en En
| LILACS, Inca
| ID: lil-673036
Biblioteca responsable:
BR30.1
ABSTRACT
Targeted monoclonal antibodies have become an important therapeutic option for patients with cancer. Cetuximab, a chimeric mouse-human (3070) immunoglobulin G1 monoclonal antibody against epidermal growth factor receptor, has been approved by the US Food and Drug Administration for the treatment of head and neck and metastatic colorectal cancer (mCRC). Severe (grade 3/4) hypersensitivity-infusion reactions (HIRs) occur in 2-3% of the patients, with fatal outcomes in 0.1%. It is recommended that patients showing severe HIRs to cetuximab should avoid further exposure to it, but in some cases there is no alternative treatment. Two options are currently available for patients with HIRs to cetuximab desensitization protocol and panitumumab. We describe here two patients with mCRC who successfully underwent a cetuximab desensitization protocol following a severe HIR to cetuximab.
Palabras clave
Texto completo:
1
Bases de datos:
LILACS
/
Inca
Asunto principal:
Inmunoglobulina G
/
Neoplasias Colorrectales
/
Anticuerpos Monoclonales
/
Metástasis de la Neoplasia
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Appl. cancer res
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article
País de afiliación:
Brasil