Your browser doesn't support javascript.
loading
An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
Migliavacca, Raphaella de Oliveira; Piltcher, Otávio Bejzman; Kliemann, Lúcia Maria; Cerski, Marcelle Reesink; Meyer, Fabíola; Oppermann, Paula de Oliveira; Machado Filho, Geraldo; Kang, Suzie Hyeona; Costa, Sady Selaimen da.
Afiliación
  • Migliavacca, Raphaella de Oliveira; Rio Grande do Sul Federal University. BR
  • Piltcher, Otávio Bejzman; Rio Grande do Sul Federal University. BR
  • Kliemann, Lúcia Maria; Rio Grande do Sul Federal University. BR
  • Cerski, Marcelle Reesink; Rio Grande do Sul Federal University. BR
  • Meyer, Fabíola; Rio Grande do Sul Federal University. BR
  • Oppermann, Paula de Oliveira; Rio Grande do Sul Federal University. BR
  • Machado Filho, Geraldo; Rio Grande do Sul Federal University. BR
  • Kang, Suzie Hyeona; Rio Grande do Sul Federal University. BR
  • Costa, Sady Selaimen da; Rio Grande do Sul Federal University. BR
Acta cir. bras ; Acta cir. bras;29(5): 313-319, 05/2014. tab, graf
Article en En | LILACS | ID: lil-709233
Biblioteca responsable: BR1.1
ABSTRACT

PURPOSE:

Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits.

METHODS:

In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa.

RESULTS:

Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026).

CONCLUSION:

It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies. .
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: LILACS Asunto principal: Sinusitis / Rinitis / Modelos Animales de Enfermedad / Seno Maxilar / Cavidad Nasal Tipo de estudio: Etiology_studies / Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2014 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: LILACS Asunto principal: Sinusitis / Rinitis / Modelos Animales de Enfermedad / Seno Maxilar / Cavidad Nasal Tipo de estudio: Etiology_studies / Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Acta cir. bras Asunto de la revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Año: 2014 Tipo del documento: Article País de afiliación: Brasil