Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction / A coreia de Sydenham persistente não está associada à disfunção sustentada de linfócitos
Torres, Karen Cecília de Lima; Rocha, Natália Pessoa; Rezende, Vítor Bortolo de; Dutra, Walderez Ornelas; Gollob, Kenneth John; Cardoso, Francisco; Teixeira, Antonio Lucio.
Arq. neuropsiquiatr;
74(1): 5-9, Jan. 2016. graf
Artículo
en Inglés
| LILACS | ID: lil-772601
The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
Biblioteca responsable:
BR1.1
Texto completo