Chromosome instability in lymphocytes from two patients affected by three sequential primary cancers: the role of fragile sites.
Cancer Genet Cytogenet
; 110(2): 133-5, 1999 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-10214362
ABSTRACT
The chromosomal aberration rate and the expression of fragile sites induced by aphidicolin were evaluated in metaphase chromosomes obtained from peripheral blood lymphocytes of two untreated patients with multiple primary cancers. Spontaneous aberrations of chromosome number and structure and chromosome fragility were compared with controls with the use of the same methods. Chromosomal aberration rates and expression frequencies of fragile sites were significantly higher in the patients than in normal control subjects. In the patients, all but one structural chromosome aberration involved at least one fragile site. Our results suggest that fragile sites may be unstable regions of the human genome, which might play an important role in the genetic instability associated with cancer predisposition.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Fragilidad Cromosómica
/
Neoplasias Urológicas
/
Neoplasias Primarias Secundarias
/
Neoplasias Gastrointestinales
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1999
Tipo del documento:
Article
País de afiliación:
España