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Chromosome 16 inversion-associated translocation: two new cases.
Maarek, O; Salabelle, A; Le Coniat, M B; Daniel, M T; Berger, R.
Afiliación
  • Maarek O; Laboratoire Central d'Hématologie Hôpital Saint Louis, Paris, France.
Cancer Genet Cytogenet ; 114(2): 126-9, 1999 Oct 15.
Article en En | MEDLINE | ID: mdl-10549269
Two patients with chromosome 16 inversion-associated translocation were studied with conventional cytogenetic and fluorescence in situ hybridization (FISH) techniques. The same chromosome 16 was involved in inversion and translocation in both patients. The chromosome translocation breakpoint was located within the heterochromatin of chromosome 16 but outside the alpha satellite domain in the t(10;16) of the first patient, whereas it was outside the heterochromatin area in the second case with t(1;16). These two types of rearrangements may be due to different mechanisms and illustrate the possible difficulties in recognizing the chromosome 16 inversion without FISH studies.
Asunto(s)
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Bases de datos: MEDLINE Asunto principal: Translocación Genética / Cromosomas Humanos Par 16 / Leucemia Mielomonocítica Aguda / Eosinofilia / Inversión Cromosómica Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cancer Genet Cytogenet Año: 1999 Tipo del documento: Article País de afiliación: Francia
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Bases de datos: MEDLINE Asunto principal: Translocación Genética / Cromosomas Humanos Par 16 / Leucemia Mielomonocítica Aguda / Eosinofilia / Inversión Cromosómica Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Cancer Genet Cytogenet Año: 1999 Tipo del documento: Article País de afiliación: Francia