Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.
Nat Med
; 5(12): 1370-4, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10581078
ABSTRACT
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
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Bases de datos:
MEDLINE
Asunto principal:
Insuficiencia Respiratoria
/
Choque Séptico
/
Receptores del Factor de Necrosis Tumoral
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos