Effects of the radical scavenger AVS on behavioral and BBB changes after experimental subarachnoid hemorrhage.
Life Sci
; 66(9): 779-90, 2000 Jan 21.
Article
en En
| MEDLINE
| ID: mdl-10698353
ABSTRACT
Free radicals are important contributors to the global brain dysfunction that follows subarachnoid hemorrhage (SAH). We evaluated the effects of hydroxyl radical scavenger AVS [(+/-)-N,N'-propylenedinicotinamide; Nicaraven] after experimental SAH on rodent behavioral deficits (employing a battery of well-characterized assessment tasks over a 2-day observation period) and blood-brain barrier (BBB) permeability changes two days after SAH (quantifying the microvascular alterations according to the extravasation of protein-bound Evans Blue using a spectrophotofluorimetric technique) in dose-response and time-window experiments. Groups of 10 rats were injected with 400 microl of autologous blood into the cisterna magna, and followed by intravenous continuous infusion of saline or 0.1, 03 or 1 mg/kg/min of AVS beginning within 5 minutes or 6 or 12 hours after SAH. The results were compared with sham-operated saline-treated and with SAH saline-treated animals. AVS significantly ameliorated performances on Beam Balance (p < 0.01) and decreased BBB permeability changes in frontal, temporal, parietal, occipital and cerebellar cortices and subcortical and cerebellar nuclei and brainstem (p < 0.01), but did not significantly affect changes in Beam Walking. This study demonstrates the neuroprotective effects of AVS when administered after experimental SAH in rats. These effects were dose-dependent and, moreover, were evident within the therapeutic window of 6-12 hours after SAH. These results reinforce the concept of a participation of reactive oxygen intermediates in the cerebral dysfunction following SAH.
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Bases de datos:
MEDLINE
Asunto principal:
Hemorragia Subaracnoidea
/
Conducta Animal
/
Barrera Hematoencefálica
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Depuradores de Radicales Libres
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Niacinamida
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia