Mitotic misregulation and human aging.
Science
; 287(5462): 2486-92, 2000 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-10741968
ABSTRACT
Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.
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Bases de datos:
MEDLINE
Asunto principal:
Progeria
/
Envejecimiento
/
Regulación de la Expresión Génica
/
Perfilación de la Expresión Génica
/
Fibroblastos
/
Mitosis
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos