Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-gamma by human CD(4)(+) T-lymphocytes.
FEBS Lett
; 472(2-3): 259-62, 2000 Apr 28.
Article
en En
| MEDLINE
| ID: mdl-10788622
ABSTRACT
Serum amyloid A (SAA) is a major acute-phase protein whose biochemical functions remain largely obscure. Human rheumatic synovial fluids were screened by high performance liquid chromatography mass spectrometry for SAA-derived peptides, specifically the sequence AGLPEKY (SAA(98-104)) which was previously shown to modulate various leukocyte functions. Two such fluids were found to contain a truncated version of SAA(98-104). Synthetic SAA(98-104) and several of its analogs were shown capable of binding isolated human CD(4)(+) T-lymphocytes and stimulating them to produce interferon-gamma. Given the high acute-phase serum level of SAA and its massive proteolysis by inflammatory related enzymes, SAA-derived peptides may be involved in host defense mechanisms.
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Bases de datos:
MEDLINE
Asunto principal:
Apolipoproteínas
/
Péptidos
/
Artritis Reumatoide
/
Proteína Amiloide A Sérica
/
Linfocitos T CD4-Positivos
/
Interferón gamma
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2000
Tipo del documento:
Article
País de afiliación:
Israel