Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability.
Nucleosides Nucleotides Nucleic Acids
; 19(3): 593-601, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10843495
ABSTRACT
2'-Deoxy-2'-S-hexyluridine derivative was synthesized from 2,2'-anhydrouridine and 1-hexanethiol and incorporated into an oligodeoxyribonucleotide. The thermal stability of the duplexes formed by the 2'-S-hexyl modified ODN with either the complementary DNA or RNA strand was decreased compared to the unmodified counterparts.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Oligodesoxirribonucleótidos
/
Oligorribonucleótidos
/
Tionucleósidos
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón