Interleukin 15 is a growth factor for human thymocytes with preferential effect on CD8(+)cells.
Cytokine
; 12(6): 751-5, 2000 Jun.
Article
en En
| MEDLINE
| ID: mdl-10843758
ABSTRACT
The effects of IL-15, as compared to IL-2, on growth of human thymocytes has been evaluated. Expression of comparable amounts of receptor chains was found on IL-2 and IL-15 cultured thymocytes, as well as comparable receptor signalling. However, IL-15 was superior to IL-2 in promoting CD8(+)thymocyte growth, whereas CD4(+)cells proliferated to a higher extent in IL-2 cultures. CD4(+)8(+)and CD4(-)8(-)thymocytes expanded equally well in both culture types.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Linfocitos T CD8-positivos
/
Interleucina-15
Límite:
Humans
Idioma:
En
Revista:
Cytokine
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Dinamarca