Soluble interleukin-2 receptor and interleukin-10 levels in patients with chronic hepatitis B infection.
Hepatogastroenterology
; 47(33): 828-31, 2000.
Article
en En
| MEDLINE
| ID: mdl-10919040
ABSTRACT
BACKGROUND/AIMS:
In the current investigation, we evaluated patients with hepatitis B infection to determine whether serum soluble interleukin-2 receptor and interleukin-10 levels were changed and whether the degree of these changes in serum levels correlated with histologic severity of hepatitis related liver injury.METHODOLOGY:
25 patients diagnosed of chronic active B hepatitis, 25 asymptomatic hepatitis B carriers, 25 healthy people with antibody to hepatitis B surface antigen and 20 healthy people without any hepatitis marker positivity were included in the study. Serum interleukin-10 and soluble interleukin-2 receptor levels were measured. The association between liver pathology, HBV DNA, serum transaminase values and these parameters were researched.RESULTS:
Serum soluble interleukin-2 receptor and interleukin-10 levels were significantly higher in chronic hepatitis cases and asymptomatic carriers than that of others (P < 0.01). Serum interleukin-10 levels correlated with histological activity index and HBV DNA values (r = 0.7, P < 0.01) but not with soluble interleukin-2 receptor levels and transaminase values.CONCLUSIONS:
Our results support the observation that interleukin-10 and soluble interleukin-2 receptor may play an important role in the inappropriate regulation of immune response in patients with chronic hepatitis B virus infection and interleukin-10 may be responsible for chronicity.
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Bases de datos:
MEDLINE
Asunto principal:
Receptores de Interleucina-2
/
Interleucina-10
/
Hepatitis B Crónica
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Año:
2000
Tipo del documento:
Article
País de afiliación:
Turquía