Simultaneous determination of benzodiazepines in whole blood or serum by HPLC/DAD with a semi-micro column.
J Pharm Biomed Anal
; 23(2-3): 447-58, 2000 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-10933538
ABSTRACT
A simple and sensitive high performance liquid chromatographic (HPLC) method using a semi-micro column, C8 reversed-phase column (3 mm i.d.) and a low flow rate 0.3 ml/min was developed and validated for the determination of five frequently prescribed benzodiazepines clonazepam, diazepam, flunitrazepam, midazolam and oxazepam. Quantification was performed at 220 nm with methylclonazepam as internal standard. The method involved a simple extraction from alkalinized blood (1 ml) into 1-chlorobutane and provided excellent sensitivity, recovery, accuracy and reproducibility for benzodiazepines in therapeutic or toxic concentrations.
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Bases de datos:
MEDLINE
Asunto principal:
Benzodiazepinas
/
Cromatografía Líquida de Alta Presión
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2000
Tipo del documento:
Article
País de afiliación:
Suiza