Mechanical control of cyclic AMP signalling and gene transcription through integrins.
Nat Cell Biol
; 2(9): 666-8, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-10980709
ABSTRACT
This study was carried out to discriminate between two alternative hypotheses as to how cells sense mechanical forces and transduce them into changes in gene transcription. Do cells sense mechanical signals through generalized membrane distortion or through specific transmembrane receptors, such as integrins? Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect.
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Bases de datos:
MEDLINE
Asunto principal:
Transcripción Genética
/
Transducción de Señal
/
AMP Cíclico
/
Integrina beta1
Límite:
Animals
Idioma:
En
Revista:
Nat Cell Biol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos