Signal transduction through prion protein.
Science
; 289(5486): 1925-8, 2000 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-10988071
ABSTRACT
The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1-dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.
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Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas PrPC
/
Caveolinas
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2000
Tipo del documento:
Article
País de afiliación:
Francia