Estrogen replacement therapy and ovarian cancer.
Eur J Gynaecol Oncol
; 21(4): 348-54, 2000.
Article
en En
| MEDLINE
| ID: mdl-11055480
ABSTRACT
Estrogen replacement therapy (ERT) has been shown to be of benefit for menopausal women, especially in prevention of coronary heart disease and osteoporotic fractures. Cancer fear is an important obstacle to use of ERT. From our literature review, there is a weak or no association between ERT and ovarian cancer risk. Individual risk of cancer should be considered before ERT use. The second issue in this review is ERT in patients with ovarian cancer. The majority of patients with ovarian cancer are postmenopausal or become menopausal after surgery. ERT is considered by many physicians to be contraindicated in patients with cancer. However, there is evidence that ERT in selected cancer patients may be of benefit for survival and quality of life. After weighing the evidence from studies on ERT in patients with ovarian, breast or endometrial cancer, we propose the use of ERT in selected ovarian cancer patients who are suffering from or are at a high risk of debilitating menopausal symptoms, osteoporosis, and coronary heart disease. The benefit of ERT to selected patient's health and quality of life appears to outweigh the risk of cancer recurrence.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Terapia de Reemplazo de Estrógeno
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
País/Región como asunto:
America do norte
/
Europa
/
Oceania
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos