Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
Nat Genet
; 26(3): 291-9, 2000 Nov.
Article
en En
| MEDLINE
| ID: mdl-11062467
ABSTRACT
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent immortalizing gene that acts by downregulating Cdkn2a (p19(ARF)). TBX2 represses the Cdkn2a (p19(ARF)) promoter and attenuates E2F1, Myc or HRAS-mediated induction of Cdkn2a (p19(ARF)). We found TBX2 to be amplified in a subset of primary human breast cancers, indicating that it might contribute to breast cancer development.
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Bases de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Biosíntesis de Proteínas
/
Cromosomas Humanos Par 17
/
Neoplasias de la Mama
/
Adenocarcinoma
/
Regulación Neoplásica de la Expresión Génica
/
Amplificación de Genes
/
Senescencia Celular
/
Proteínas de Ciclo Celular
/
Proteínas de Dominio T Box
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Nat Genet
Asunto de la revista:
GENETICA MEDICA
Año:
2000
Tipo del documento:
Article
País de afiliación:
Países Bajos