Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei.
J Neurosci
; 21(15): RC158, 2001 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-11459879
ABSTRACT
The spatial distribution of low-voltage-activated (LVA) and high-voltage-activated (HVA) barium currents was investigated in neurons of the deep cerebellar nuclei (DCN) by combining barium imaging with voltage clamp. The current-induced fluorescence signal (DeltaF/F) of the HVA current was five times higher then the LVA-induced signal at the soma, but both signals were approximately equal in size in distant dendrites. This position-dependent shift of DeltaF/F indicates a non-uniform distribution of the underlying calcium channels. The higher weight of the LVA signal in the dendrites suggests that the LVA might be of particular relevance for the dendritic integration of synaptic inputs.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Canales de Calcio
/
Núcleos Cerebelosos
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania