Comparison of protease genotype and phenotype in HIV-1 infected patients exposed to more than one protease inhibitor.
J Biol Regul Homeost Agents
; 15(2): 166-9, 2001.
Article
en En
| MEDLINE
| ID: mdl-11501975
ABSTRACT
Many patterns of mutations selected by HIV-1 protease inhibitors have been described, but in most cases isolates with these patterns have been obtained from pre-clinical studies or after failures of monotherapies. We compared genotype and phenotype in HIV-1 infected patients who have failed more than one PI-including regimen. Phenotypic resistance could arise also in the absence of specific primary mutations and in the presence of different substitutions among those known to confer resistance to ritonavir, indinavir or nelfinavir. The number of secondary mutations was significantly associated with phenotypic resistance for each protease inhibitor. Thus, more study of mutational patterns in heavily pretreated patients is warranted; in the mean time treatment choices might be optimized if phenotyping could integrate genotyping within this setting.
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Bases de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Proteasa del VIH
/
VIH-1
/
Inhibidores de la Proteasa del VIH
Límite:
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia