Growth hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women.
Horm Res
; 55(3): 131-6, 2001.
Article
en En
| MEDLINE
| ID: mdl-11549874
ABSTRACT
AIM:
The aim of this study was to investigate the effect of baclofen administration on growth hormone (GH) secretion during different phases of the menstrual cycle.METHODS:
Twelve healthy women (33.6 +/- (SD) 2.8 years; range 23-40 years) with regular menstrual cycles were enrolled. The phases of the menstrual cycle were determined using transvaginal ultrasonography (TV-US) and detecting hormonal serum levels. Plasma GH levels were evaluated during the early follicular, periovulatory and luteal phases of the cycle before and after the baclofen challenge test.RESULTS:
After acute baclofen administration, GH levels increased significantly (p < 0.001) compared to basal values during the periovulatory and luteal phases, while no significant variation was detected during the early follicular phase. In addition, plasma GH levels resulted significantly (p < 0.001) higher during the luteal phase than during the periovulatory phase.CONCLUSION:
Acute baclofen administration induces a significant increase in plasma GH levels in healthy females during the periovulatory and luteal phases, but not during the early follicular phase. These data suggest a modulator role of plasma sex steroids levels on GH release induced by baclofen.
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Bases de datos:
MEDLINE
Asunto principal:
Baclofeno
/
Hormona del Crecimiento
/
Ciclo Menstrual
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Horm Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Italia