Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation.
Arch Dermatol
; 137(9): 1208-13, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11559219
ABSTRACT
OBJECTIVES:
To determine the efficacy of systemic corticosteroid therapy in treating enlarging, problematic cutaneous hemangiomas and to assess the relationship of dose to response and adverse effects.DESIGN:
A quantitative systematic literature review was performed and inclusion and exclusion criteria were applied.SETTING:
Patients were treated in primary care, referral centers, and institutional practices. Most patients were ambulatory, although some required hospitalization. PATIENTS Inclusion criteria were original case series with a minimum of 5 patients with enlarging, problematic cutaneous hemangiomas treated with systemic corticosteroids. Exclusion criteria were being older than 2 years, receiving simultaneous other treatments, being lost to follow-up, or having insufficient information. Twenty-four original case series met inclusion criteria; 10 case series remained (184 patients) after exclusion criteria were applied. INTERVENTION Patients were given a mean prednisone equivalent daily dose of 2.9 mg/kg (95% confidence interval [CI], 2.7-3.1 mg/kg) for a mean of 1.8 months (95% CI, 1.5-2.2 months). MAIN OUTCOMEMEASURES:
Response and rebound rates and dose-response and adverse effects-response relationships in responders vs nonresponders.RESULTS:
Response was 84% (95% CI, 78%-89%; range, 60%-100%) and rebound was 36% (95% CI, 29%-44%; range, 0%-65%). A significant difference was found between the mean dose administered to responders vs nonresponders (P<.001). No significant difference was observed as to the occurrence of adverse effects (P =.3).CONCLUSION:
Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy.
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Bases de datos:
MEDLINE
Asunto principal:
Corticoesteroides
/
Medicina Basada en la Evidencia
/
Hemangioma
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Arch Dermatol
Año:
2001
Tipo del documento:
Article
País de afiliación:
Estados Unidos