Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis.
Thromb Res
; 103 Suppl 1: S1-5, 2001 Sep 30.
Article
en En
| MEDLINE
| ID: mdl-11567663
ABSTRACT
Increased expression of plasminogen activator inhibitor type 1 (PAI-1) is now considered as an independent risk factor for cardiovascular disease. Numerous biochemical factors have been found to regulate the expression of PAI-1 gene and the synthesis of PAI-1 protein. In the recent past, polymorphisms in the PAI-1 gene have been identified and their impact on PAI-1 expression has been characterized. This article will review the current knowledge of these PAI-1 gene polymorphisms (in cell culture epidemiological, and clinical studies) and their role in the development of cardiovascular disease.
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Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Enfermedades Cardiovasculares
/
Inhibidores de Serina Proteinasa
/
Inhibidor 1 de Activador Plasminogénico
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Thromb Res
Año:
2001
Tipo del documento:
Article
País de afiliación:
Alemania