Hemophagocytic syndrome: a rare life-threatening complication of visceral leishmaniasis in a young boy.
Pediatr Hematol Oncol
; 18(8): 531-6, 2001 Dec.
Article
en En
| MEDLINE
| ID: mdl-11764103
ABSTRACT
The authors report a case of hemophagocytic syndrome (HPS) associated with acute visceral leishmaniasis (VL). A 4-year-old boy was admitted with high fever, hepatosplenomegaly, and pancytopenia. Elevated serum ferritin and triglyceride, low fibrinogen levels, and bone-marrow (BM) histiocytic hyperplasia with prominent hemophagocytosis were consistent with a HPS. An initial diagnosis of kala-azar was refuted because of negativity of BM aspiration and serology for this parasite, and the diagnosis HPS was made. Three months after first admission, reevaluation of the BM aspiration revealed many amastigotes of Leishmania parasites. The serology of VL became positive, finally establishing the diagnosis of VL. Although specific therapy for VL was instituted, the patient died 4 weeks after the diagnosis.
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Bases de datos:
MEDLINE
Asunto principal:
Histiocitosis de Células no Langerhans
/
Leishmaniasis Visceral
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Turquía