Inhibition of autoimmune encephalomyelitis by a tetracycline.
Ann Neurol
; 51(2): 215-23, 2002 Feb.
Article
en En
| MEDLINE
| ID: mdl-11835378
We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.
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Bases de datos:
MEDLINE
Asunto principal:
Encefalomielitis Autoinmune Experimental
/
Minociclina
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Ann Neurol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos