[Expression of telomerase genes in mamary atypical ductal hyperplasia].
Zhonghua Bing Li Xue Za Zhi
; 31(1): 30-3, 2002 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-11955332
ABSTRACT
OBJECTIVE:
To investigate the relationship of telomerase genes and the malignant transformation of atypical mammary ductal hyperplasia.METHODS:
Telomerase genes hTR and hTRT in 50 cases of mammary hyperplasia (the cases included 6 benign hyperplasia, 9 mild atypical hyperplasia, 12 medium atypical hyperplasia, 23 severe atypical hyperplasia) and 26 cases of breast carcinoma were detected by in situ hybridization.RESULTS:
The expression of hTR and hTRT mRNA were weak or negative in benign hyperplasia (1/6, 0), weaker in mild-moderate atypical hyperplasia (2/9, 1/9, 4/12, and 3/12), strong in severe atypical hyperplasia (14/23, 60.9% and 12/23, 52.1%), while very strong expression (23/26, 88.5% and 21/25, 80.8%) in carcinoma of the breast. The difference between mild-moderate atypical hyperplasia, invasive ductal carcinoma and severe atypical hyperplasia was significant (P < 0.05) and the difference between severe atypital hyperplasia and intraductal carcinoma was not significant (P > 0.05).CONCLUSIONS:
Telmerase genes (hTR, hTRT) expression is closely related to the malignant transformation of atypical hyperplasia. The reactivated telomerase may play a crucial role in the development of breast cancer.
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Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Expresión Génica
/
Carcinoma Intraductal no Infiltrante
/
Telomerasa
Límite:
Female
/
Humans
Idioma:
Zh
Revista:
Zhonghua Bing Li Xue Za Zhi
Año:
2002
Tipo del documento:
Article
País de afiliación:
China