Solubility prediction in supercritical CO(2) using minimum number of experiments.
J Pharm Sci
; 91(5): 1287-95, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-11977104
ABSTRACT
The correlation ability and solubility prediction in supercritical carbon dioxide of a proposed equation were studied. The work involved the solubilities of nicotinic acid and p-acetoxyacetanilide in supercritical carbon dioxide using a dynamic flow solubility system at 35-75 degrees C and 100-200 bar. The generated experimental solubility data together with 21 data sets collected from the literature were used to evaluate the correlation ability of available empirical equations. The average absolute relative deviations (AARD) for the empirical equations are 12.6-24.8%. The prediction capability of the modified empirical relationship was studied with six experimental data points as a training set. Then, solubility at other temperatures and pressures were predicted. The AARD between predicted solubilities and observed values is 17%.
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Bases de datos:
MEDLINE
Asunto principal:
Dióxido de Carbono
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Pharm Sci
Año:
2002
Tipo del documento:
Article
País de afiliación:
Irán