Crystallization and solid-state reaction as a route to asymmetric synthesis from achiral starting materials.
J Mol Evol
; 6(2): 99-115, 1975 Oct 29.
Article
en En
| MEDLINE
| ID: mdl-1202235
ABSTRACT
Many molecules which are achiral can crystallize in chiral (enantiomorphic) crystals and, under suitable conditions, crystals of only one chirality may be obtained. The formation of right- or left-handed crystals in excess is equally probable. Lattice-controlled (topochemical) photochemical or thermal solid-state reactions may then afford stable, optically active products. In the presence of the chiral products, achiral reactants may preferentially produce crystals of one chirality, leading to a feedback mechanism for the generation and amplification of optical activity. Amplification of optical activity can also be achieved by solid-state reactions. The optical synthesis of biologically relevant compounds by such routes may be envisaged.
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Bases de datos:
MEDLINE
Asunto principal:
Cristalización
/
Evolución Biológica
/
Isomerismo
Idioma:
En
Revista:
J Mol Evol
Año:
1975
Tipo del documento:
Article